SPECIFIC LANGUAGE DISORDER--GENETICS AND EPIDEMIOLOGY

该提案描述了一项旨在确定 导致特定疾病家族聚集的因素 家庭语言障碍。 拟议的研究将 确定诊断所需的临床措施 成人的特殊语言障碍。 这些措施将 与一套现有的儿童措施相结合， 确定是否存在特定语言障碍（先证者）。 将生成特定语言障碍的谱系。 利用这些谱系，将进行复杂的分离分析。 确定是否有一个主要的遗传位点，如 以及遗传异质性存在于 这些家庭表现出高密度的特定语言， disorder. DNA和白细胞将从血液中提取 以便于将来的分析。 这项研究旨在提高我们对 一种发展性语言障碍的原因， 主要表现是语言发展的缺陷， 听觉灵敏度和非语言能力 智能 通过确定这个家族的基础 聚集，改善早期识别和预防可能是 可能

This proposal describes a research program designed to determine the factors that contribute to the familial aggregation of specific language disorders in families. The proposed research will identify those clinical measures necessary for the diagnosis of specific language disorders in adults. These measures will then be combined with a set of existing measures for children to determine the presence of specific language impairment (probands). Pedigrees for specific language impairment will be generated. Using these pedigrees, complex segregation analysis will be performed to determine whether there is a major genetic locus, as well as the extent to which genetic heterogeneity is present in these families showing a high density of specific language disorder. The DNA and leukocytes will be recovered from this blood for the purposes of future analysis. This research is concerned with improving our understanding of the causes of a form of developmental language disorder in which the primary manifestation is a deficit in language development in spite of apparently normal auditory sensitivity and nonverbal intelligence. By determining the basis of this familial aggregation, improved early identification, and prevention may be possible.