BRAINSTEM EVOKED AUDITORY RESPONSE

可以从头皮记录的声音诱发电位是 在各种疾病的临床诊断中日益重要 影响中枢神经系统的疾病，如肿瘤和多发性 硬化症。特别是，所谓的短延迟组件 (脑干听觉诱发电位，BSEP)已被证明非常有用 做出这样的诊断。该方法在精确定位病变部位中的应用 然而，由于不确定具体位置，测试受到了阻碍。 反应的各个组成部分的神经生成器。其目的是 这项研究的目的是为了更好地了解 可以从头皮记录的远场电事件 在瞬变声音开始后的第一个10毫秒，并识别 这些电势的神经生成器。这将通过以下方式完成 神经外科手术和手术中人类的颅内记录 动物实验。来自不同大脑核团的选择性记录将 在人体和动物实验中都是如此。可能会发生 某些神经束或神经核是大脑的某些部分的生成器 将通过确定头皮记录的BSEP的幅度来研究 反应和发电器的解剖延伸。实验将会 在狒狒身上执行脉动压力对不同的影响 部分听觉神经系统将使用植入物进行研究。 气球。反应对不同类型刺激的依赖性 将探索以找到不同类型的最优刺激 学习。更好地理解这些电势的起源和 它们对刺激参数的依赖将增加临床价值 这一测试方法并扩大了其在疾病鉴别诊断中的应用 折磨着听觉神经系统。

The sound evoked potentials that can be recorded from the scalp are becoming of increasing importance in the clinical diagnosis of various diseases affecting the central nervous system such as tumors and multiple sclerosis. In particular, the so-called short latency components (brainstem auditory evoked potentials, BSEP) have proven to be very useful in making such diagnoses. The use of this method in precise site-of-lesion testing is, however, hampered by uncertainty as to the exact location of the neural generators of the various components of the response. The aim of this study is to obtain a better understainding of the sources of the farfield electrical events that can be recorded from the scalp during the first 10 msec after the onset of a transient sound and to identify the neural generators of these potentials. This will be done through intracranial recordings in humans during neurosurgical operations and in animal experiments. Selective recordings from different brain nuclei will be made in both the human and animal experiments. The likelihood of a certain nerve tract or nucleus being the generator of certain parts of the scalp-recorded BSEP will be studied by determining the amplitude of the response and the anatomical extension of the generator. Experiments will be performed in baboons where the effect of pulsatile pressure on different parts of the auditory nervous system will be studied using implantable balloons. The dependence of the response on different types of stimuli will be explored in order to find optimal stimuli for different types of studies. A better understanding of the origin of these potentials and their dependence on stimulus parameters will increase the cllnical value of this test method and broaden its use in differential diagnosis of disorders afflicting the auditory nervous system.