DIAGNOSTIC IMAGING OF CRANIOSYNOSTOSES

三维计算机断层扫描(3DCT)的一个主要应用领域 是对头部的成像。3DCT在确定 先天性和获得性颅面畸形的存在和程度。 这项建议的目标是比较敏感度和 3DCT图像在诊断和定性诊断卵巢癌中的特异性 颅骨融合的平面CT和常规头颅X线片诊断 具体说明观察者的经验在解释 这些基于图像的诊断。200名患者(100名患者和100名患者 如无接合，则行CT、3DCT及头颅平片检查。 将测试观察者体验的成像方式和水平 与ROC分析有显著差异。我们假设3DCT是 明显优于其他成像系统的勾画 颅缝融合与3DCT观察者经验的重要性 将显著减少。

A major area of application of three dimensional computed tomography (3DCT) is imaging of the head. 3DCT has an important role in determining the presence and extent of congenital and acquired craniofacial deformities. The objectives of this proposal are to compare the sensitivity and specificity of 3DCT images in the detection and characterization of craniosynostosis with that of planar CT and routine skull x-rays and to specify the role played by observer experience in the interpretation of these image-based diagnoses. Two hundred patients (100 with and 100 without synostoses will be imaged with CT, 3DCT, and plain skull x-rays. Imaging modalities and levels of observer experience will be tested for significant differences with ROC analysis. We hypothesize that 3DCT is significantly better than other imaging systems for the delineation of craniosynostosis and that for 3DCT the importance of observer experience will be significantly less.