INITIAL LESION OF ADULT PERIODONTITIS

本提案的长期目标是检测和 微生物学特征的初始牙周病变。 电流 关于这些受试者中疾病活动率的信息很少。 本研究比较了临床和微生物 成人牙周炎初期病变的特点， 牙龈炎和健康。 临床、微生物和免疫学特征 将寻求区分渐进性依恋丧失， 牙龈炎和健康。 第一个目标将确定初始的临床特征。 成人牙周病。 健康和牙龈炎受试者将 使用电子温度和附件进行纵向监测 水平探针寻找显示牙周显著损失的部位 疾病活动度（Disease Activity） 牙龈炎人群将是 通过筛选具有升高的 龈下温度 临床特征比较 活动性病变的部位和受试者，牙龈炎部位 牙龈炎受试者和健康受试者的健康部位， 指出哪些特征与疾病活动有关， 包括体温升高在内的临床特征是 疾病活动的风险增加。 为了确定最初牙周病变的病因， 主要的可培养微生物群将从疾病活动中确定， 位点，并与牙龈炎中的牙龈炎位点进行比较 受试者和健康受试者的健康部位。 比较 牙龈炎和健康部位的活动性病变的微生物群应 指出哪些物种与进行性疾病有关，以及 任何微生物都是转化风险的有用指标， 健康或牙龈炎到活动性疾病。 将寻求血清抗体 优势龈下物种的免疫学特征， 初期牙周病变。 最终，这些信息将有助于早期识别 牙周炎发病风险升高的受试者，并改善我们的 了解牙周病的初期阶段。

The long term objective of this proposal is to detect and microbiologically characterize the initial periodontal lesion. Current information on the rate of disease activity in such subjects is minimal. This investigation compares the clinical and microbiological characteristics of the initial lesion of adult periodontitis, with gingivitis and health. Clinical, microbial and immunologic features will be sought that discriminate between progressive attachment loss, gingivitis, and health. The first aim will determine clinical features of the initial periodontal lesion in adults. Healthy and gingivitis subjects will be monitored longitudinally using electronic temperature and attachment level probes seeking sites showing significant losses in periodontal attachment level (disease activity). The gingivitis population will be enriched for active sites by screening for subjects with elevated subgingival temperatures. Comparison of clinical characteristics of sites and subjects with active lesions, with gingivitis sites from gingivitis subjects, and healthy sites from healthy subjects, should indicate which features are related to disease activity, and whether any clinical features including increased temperature are indicators for elevated risk for disease activity. To determine the etiology of the initial periodontal lesion, the predominant cultivable microbiota will be determined from disease active sites, and compared with that of gingivitis sites in gingivitis subjects, and with healthy sites in healthy subjects. Comparison of the microbiota of active lesions with gingivitis and healthy sites should indicate which species are related to progressive disease, and whether any microorganisms are useful indicators of the risk for conversion of health or gingivitis to active disease. Serum antibodies will be sought to dominant subgingival species to immunologically characterize the initial periodontal lesion. Ultimately, this information will contribute to early identification of subjects at elevated risk for onset of periodontitis, and improve our understanding of the initial stage of periodontal disease.