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中文摘要
翻译
这项拟议中的研究将评估免疫和 胰岛素依赖风险的环境决定因素 糖尿病(IDDM)。 具体而言,我们将: 1. 监测宾夕法尼亚州阿勒格尼县的胰岛素依赖型糖尿病发病率, 25年(1965-1990年),以及世界。 2. 评估特定血清学和 90例同胞中胰岛素依赖型糖尿病危险性的分子标记 58个受影响的父母子女家庭,60个单身家庭, 个案家庭 3. 评估病毒DNA插入到 人类基因组和胰岛素依赖型糖尿病。 4. 继续收集一级亲属的样本 转化为IDDM之前的病例。
英文摘要
The proposed research will evaluate the immunologic and environmental determinants of the risk of insulin dependent diabetes mellitus (IDDM). Specifically, we will: 1. Monitor the incidence of IDDM in Allegheny County, PA, over 25 years (1965-1990) as well as the world. 2. Assess the associations between specific serologic and molecular markers to the risk of IDDM in 90 multiple sibling families, 58 affected parent offspring families, and 60 single case families. 3. Evaluate the association between viral DNA insertion into the human genome and IDDM. 4. Continue to collect samples on first degree relatives of cases prior to conversion to IDDM.
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ETIOLOGY AND EPIDEMIOLOGY OF INSULIN DEPENDENT DIABETES MELLITUS
RESEARCH TRAINING IN PEDIATRIC ENDOCRINOLOGY & DIABETES
DIABETES CONTROL AND COMPLICATIONS TRIAL
DIABETES CONTROL AND COMPLICATIONS TRIAL
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