REGULATION OF GLOMERULAR AND PROXIMAL NEPHRON FUNCTION

该项目的目标是确定延髓旁肾单位是否 肾脏表现出对其肾小球比率进行反馈控制的能力 过滤。在一系列开环实验中，肾小管球蛋白 反馈将在延髓旁和浅层肾单位进行测量 保水利尿的仓鼠肾脏。Henle氏环灌流的疗效观察 滤过率和灌流液成分对同一肾单位的滤过率 量过了。在一系列的闭环实验中，它将是 确定肾小管球反馈是否介导延髓旁肾单位 肾小球滤过率的自动调节。通过测量近髓 肾小球滤过率不影响肾小管小球机制 反馈利尿期间，将确定是否增加了亨勒的循环 利尿引起的血流导致单个肾单位滤过率降低。 通过激活延髓旁肾小管球反馈。一个整体 研究的一部分是亨勒回路函数的数学模型。这个 模拟循环水和溶质重吸收的模型被用于 实验设计和数据解释。

The goal of the project is to determine whether juxtamedullary nephrons of the kidney exhibit the ability to exert feedback control on their rate of glomerular filtration. In a series of open-feedback-loop experiments, tubuloglomerular feedback will be measured in juxtamedullary and superficial nephrons in hydropenic and diuretic hamster kidneys. The effects of Henle's loop perfusion rate and perfusate composition on filtration rate in the same nephron will be measured. In a series of closed-feedback-loop experiments, it will be determined whether tubuloglomerular feedback mediates juxtamedullary nephron autoregulation of glomerular filtration rate. By measuring juxtamedullary nephron filtration rate without interrupting the mechanism of tubuloglomerular feedback during diuresis, it will be determined if the increased loop of Henle flow due to the diuresis leads to a reduction in single nephron filtration rate by activating juxtamedullary nephron tubuloglomerular feedback. An integral part of the research is a mathematical model of Henle's loop function. The model, which stimulates loop water and solute reabsorption, is used for experimental design and data interpretation.