17-ERACoBioTech-Bester

工业生物技术是一项关键的使能技术，可以从可持续资源中生产出大量不同的生物基产品，也是欧洲发展生物基经济的驱动力。特种化学品行业是一个4500亿美元的市场，是5.4万亿美元全球化学品市场的一部分。在这个市场中，丁基酯，由正丁醇（BuOH）和适当的有机酸通过酯化反应衍生而来，作为商品化学品和替代生物燃料有多种用途，但在香料和香料工业、化妆品和涂料中也代表着高价值的机会。在厌氧梭菌ABE发酵过程中生产BuOH已经很好地建立了，并于2016年由英国公司和BESTER项目合作伙伴Green Biologics Ltd. （GBL）在美国达到了商业规模。需要利用可再生资源生产合适的有机酸，作为催化酯化反应中丁氢醇的对应物。使用酯酶作为天然的、可持续生产的酯形成生物催化剂，将使生产不同丁基酯的生物过程完全绿色，从而增加ABE工艺的市场价值并减少温室气体排放。BESTER项目将来自四个不同的era - cobiotechnology伙伴国（挪威、英国、德国和法国）的具有高度互补专业知识的六个项目合作伙伴联系起来，以最大限度地提高项目产出并分担风险、成本和技能。该项目由大型企业GBL（英国）和SME Processium SA （FR）作为积极的合作伙伴参与。Borregaard AS将提供专家建议和该公司专有的BALI工艺发酵原料。这三家公司沿着丁基酯价值链定位，这将确保项目成果有效地进一步走向商业化。BESTER项目将减轻化工生产对化石的依赖，实现欧洲工业的可持续发展。

Industrial Biotechnology is a key enabling technology to produce a plethora of different bio-based products from sustainable resources and a driver for developing the bio-based economy in Europe. The specialty chemical industry is a $450 billion market and is a part of the $5.4 trillion global chemical market. Within this market, butyl esters, derivable from n-butanol (BuOH) and suitable organic acids by esterification, have diverse uses as commodity chemicals and drop-in biofuels, but also represent high value opportunities within the fragrance and flavour industry, cosmetics and coatings. The production of BuOH in the anaerobic clostridial ABE fermentation process is well established and has in 2016 reached commercial scale in the US by UK-based company and BESTER project partner Green Biologics Ltd. (GBL). Efficient processes to produce suitable organic acids from renewable resources as counterparts for BuOH in catalytic esterification are needed. The use of esterase enzymes as natural, sustainably produced biocatalysts for ester formation will allow entirely green bioprocesses for the production of different butyl esters, thus increasing market value of the ABE process and reducing GHG emissions.The BESTER project connects six project partners with highly complementary expertise from four different ERA-CoBioTech partner countries (Norway, UK, Germany and France) in order to maximise project output and share risks, costs and skills. The project is industry-driven with large enterprise GBL (UK) and SME Processium SA (FR) participating as active partners. Borregaard AS will provide expert advice and fermentation feedstock from the company's proprietary BALI process. The three companies are positioned along the butyl ester value chain, which will ensure that project results are efficiently taken further towards commercialization. BESTER project will mitigate reliance on fossils for chemical production, enabling sustainable industrial development in Europe.