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17-ERACoBioTech - SUSPHIRE - Sustainable Bioproduction of Pheromones for Insect Pest Control in Agriculture

17-ERACoBioTech - SUPHIRE - 用于农业害虫防治的信息素可持续生物生产

基本信息

批准号：
BB/R021554/1
负责人：
Nicola Joan Patron
金额：
$ 50.37万
依托单位：
Earlham Institute
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FR021554%2F1
关键词：
17 ERACoBioTech SUSPHIRE Sustainable Bioproduction

项目摘要

The aim of this project is to enable bio-based manufacturing of insect pheromones in plants and fungi for the sustainable control of insect pests of agriculture and horticulture. This project builds on a proof-of-concept in which moth sex-pheromones were produced in plants.Some of the most aggressive pests of agriculture are insect larvae. Semiochemicals are chemicals emitted by insects for communication. The most widely known of these are sex pheromones, produced by virgin females to attract mates of the same species. Dispensing insect sex pheromones in plant production environments is used to trigger sexual confusion in the target species and prevent breeding, thereby providing a highly species-specific control method. This presents a sustainable alternative to conventional pesticides, the use of which are progressively being restricted due to concerns about their non-specificity and negative impacts on biodiversity. Insect sex pheromones are already used as a pest-control strategy; however, chemical synthesis is currently the only approach for manufacturing and the use of toxic ingredients and the creation of toxic by-products is inevitable for some pathways. Further, the unusual chemical characteristics of many insect pheromones mean that chemical synthesis strategies are not cost effective. For example, Coccoidea species (scale insects and mealybugs) are aggressive pests of agriculture and horticulture and better control methods are highly desirable. However, their sex pheromones have unusual structures for which chemical synthesis is both difficult and expensive.Previous studies by SUSPHIRE partners demonstrated that it is possible to engineer N. benthamiana plants to produce high quantities of moth sex pheromones. The SUSPHIRE project will improve on this initial proof-of-concept and will also identify and validate the genes in the Coccoidea pheromone biosynthetic pathway. We aim to optimize bioproduction of insect pheromones in plants and fungi and to evaluate the pheromones produced in these species in laboratory and field conditions.The SUSPHIRE project aims to provide a sustainable, low-cost manufacturing platform for the commercial production of insect pheromones and reduce the cost of production of pheromones that are currently commercially non-viable. The introduction of these biotechnology approaches to pheromone production will expand the use of sex pheromones for sustainable pest control in agriculture, reducing its current environmental impact and providing sustainable manufacturing platforms.

该项目的目的是能够在植物和真菌中以生物为基础制造昆虫信息素，以可持续地控制农业和园艺业的害虫。这个项目建立在一个概念验证的基础上，在这个概念验证中，蛾类的性信息素是在植物中产生的。一些最具攻击性的农业害虫是昆虫幼虫。信息化学物质是昆虫为交流而排放的化学物质。其中最广为人知的是性信息素，由处女雌性产生，以吸引同一物种的配偶。在植物生产环境中分配昆虫性信息素被用来在目标物种中引发性别混乱并防止繁殖，从而提供了一种高度物种特异性的控制方法。这为传统杀虫剂提供了一种可持续的替代品，由于担心其非特异性和对生物多样性的负面影响，传统杀虫剂的使用正逐渐受到限制。昆虫性信息素已经被用作害虫控制策略；然而，化学合成目前是制造和使用有毒成分的唯一方法，对于某些途径来说，产生有毒副产品是不可避免的。此外，许多昆虫信息素的不同寻常的化学特性意味着化学合成策略并不划算。例如，椰子总科物种(介壳虫和粉虱)是农业和园艺的侵略性害虫，非常需要更好的控制方法。然而，它们的性信息素具有不寻常的结构，化学合成既困难又昂贵。SUSPHIRE合作伙伴之前的研究表明，通过改造本色夜蛾植物来生产大量的蛾性信息素是可能的。SUSPHIRE项目将改进这一最初的概念验证，并将识别和验证瓢虫总目信息素生物合成途径中的基因。我们的目标是优化昆虫信息素在植物和真菌中的生物生产，并在实验室和田间条件下评估这些物种产生的信息素。SUSPHIRE项目旨在为昆虫信息素的商业生产提供一个可持续的、低成本的制造平台，并降低目前商业上不可行的信息素的生产成本。将这些生物技术方法引入信息素生产将扩大性信息素在农业可持续虫害控制中的使用量，减少其目前对环境的影响，并提供可持续的制造平台。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Rational design of minimal synthetic promoters for plants.

DOI：
10.1093/nar/gkaa682
发表时间：
2020-12-02
期刊：
Nucleic acids research
影响因子：
14.9
作者：
Cai YM;Kallam K;Tidd H;Gendarini G;Salzman A;Patron NJ
通讯作者：
Patron NJ

Engineering of a Plant Isoprenyl Diphosphate Synthase for Development of Irregular Coupling Activity.

DOI：
10.1002/cbic.202100465
发表时间：
2022-01-05
期刊：
CHEMBIOCHEM
影响因子：
3.2
作者：
Gerasymenko, Iryna;Sheludko, Yuriy, V;Fuertes, Ismael Navarro;Schmidts, Volker;Steinel, Lara;Haumann, Elisabeth;Warzecha, Heribert
通讯作者：
Warzecha, Heribert

Transcriptional deregulation of stress-growth balance in Nicotiana benthamiana biofactories producing insect sex pheromones.

DOI：
10.3389/fpls.2022.941338
发表时间：
2022
期刊：
Frontiers in plant science
影响因子：
5.6
作者：
通讯作者：

Tunable control of insect pheromone biosynthesis in Nicotiana benthamiana.

DOI：
10.1111/pbi.14048
发表时间：
2023-07
期刊：
PLANT BIOTECHNOLOGY JOURNAL
影响因子：
13.8
作者：
Kallam, Kalyani;Moreno-Gimenez, Elena;Mateos-Fernandez, Ruben;Tansley, Connor;Gianoglio, Silvia;Orzaez, Diego;Patron, Nicola
通讯作者：
Patron, Nicola

Biofoundry-assisted expression and characterization of plant proteins.

植物蛋白的生物基础辅助表达和表征。