IS BENZYL ACETATE A PANCREATIC CARCINOGEN?

本项目的目标是评估乙酸苄酯作为胰腺炎的治疗方法。 啮齿动物胰腺中的致癌物质。 胰腺癌是一个主要的原因 在美国，癌症死亡率是10%，因为这种疾病是在一个 治疗无效的晚期临床阶段。 认识到 因此，这种癌症特别重要。 最近的一项生物测定 国家毒理学计划进行的一项研究表明， 醋酸盐，一种食品和化妆品添加剂和天然产物， 雄性F-344大鼠胰腺外分泌腺瘤。 解释 这一发现的意义是复杂的事实， 腺瘤的总体发病率很低，而且玉米油 用作通过管饲法施用乙酸苄酯的媒介物。 一 回顾性评价2005年10月至2007年12月间美国胰腺腺泡细胞腺瘤的发病率， 通过管饲法给予玉米油的F-344大鼠的“对照”组显示， 与对照组相比， 没有玉米油。 具体目的是评估乙酸苄酯对胰腺的影响 在没有玉米油灌胃的情况下;比较F-344的反应性 和刘易斯品系大鼠对乙酸苄酯的作用;比较 通过在椰子油中的管饲法和通过混合 评价乙酸苄酯对雄性胰腺的影响 大鼠进行长期研究;并评价乙酸苄酯在 仓鼠胰腺的初步研究。 胰腺癌的发病率 腺瘤、癌和前驱病变将通过尸检确定 和组织学评价。

The goal of this project is to evaluate benzyl acetate as a pancreatic carcinogen in rodent pancreas. Carcinoma of the pancreas is a major cause of cancer deaths in the United States because the disease is diagnosed at a late clinical stage when therapy is ineffective. Recognition of causes of this cancer is therefore of special importance. A recent bioassay conducted by the National Toxicology Program has suggested that benzyl acetate, a food and cosmetic additive and a natural product, induces adenomas in the exocrine pancreas of male F-344 rats. Interpretation of the significance of this finding is complicated by the fact that the overall incidence of the adenomas was low, and by the fact that corn oil was used as a vehicle for administration of benzyl acetate by gavage. A retrospective evaluation of the incidence of acinar cell adenomas in "control" groups of F-344 rats given corn oil by gavage has shown an increased incidence in males in comparison with control groups that were not given corn oil. Specific aims are to evaluate the effect of benzyl acetate on the pancreas in the absence of corn oil gavage; to compare the responsiveness of F-344 and Lewis strain rats to benzyl acetate; to compare the efficacy of administration of benzyl acetate by gavage in coconut oil and by mixing in the diet; to evaluate the effect of benzyl acetate on the pancreas of male rats in a long-term study; and to evaluate the effect of benzyl acetate in the hamster pancreas in a pilot study. The incidence of pancreatic adenomas, carcinomas, and precursor lesions will be determined by autopsy and histologic evaluation.