ABNORMAL RETINAL POTENTIALS IN GLAUCOMA AND OCULAR HYPER

模式翻转视网膜电位(PRRP)是生物电信号， 在近端视网膜层内产生，可从 当观察到相交刺激时，人眼的角膜。我们的 以往的研究表明，PRRP的幅度显著地 原发性开角型青光眼(POAG)患者较 年龄匹配的视觉正常者(AMVNs)。此外，我们的结果表明， 这种PRRP幅度降低的幅度在视觉上最大 刺激是以高时间速率(即每个周期16次反转)交替的 第二)。这表明POAG的发展产生了很高的 人的时间调谐特性中的频率衰减 PRRP。此外，我们还注意到，高眼压症患者 (OHT)和老年视力正常者(70-79岁)可能出现PRRP 高时间频率刺激的幅度降低。这些 观察提出了以下三个假设，这些假设将在 拟议的调查：1)PRRP幅度的降低提供 哪些眼部高血压患者将发展成可靠的预后指标 POAG(纵向研究)，2)PRRP波幅显著降低 低眼压性青光眼患者(一项横断面研究)和3)正常 生理性衰老导致PRRP幅度(A)进行性降低 横断面研究)。

Pattern-reversal retinal potentials (PRRPs) are bioelectrical signals, generated within the proximal retinal layers, which can be recorded from the cornea of the human eye when phase-alternating stimuli are viewed. Our previous investigations have revealed that PRRP amplitude is significantly reduced in patients with primary open-angle glaucoma (POAG) relative to age-matched visual normals (AMVNs). Furthermore, our results indicate that the magnitude of this PRRP amplitude reduction is greatest when the visual stimuli are phase-alternated at a high temporal rate (i.e. 16 reversals per second). This suggests that the development of POAG produces a high frequency attenuation in the temporal tuning characteristic of the human PRRP. Additionally, we have noted that patients with ocular hypertension (OHT) and elderly visual normals (70-79 years of age) may exhibit PRRP amplitude reductions for high temporal frequency stimuli. These observations suggest the following three hypotheses which will be tested in the proposed investigation: 1) Reductions in PRRP amplitude provide reliable prognostic indications of which ocular hypertensives will develop POAG (a longitudinal study), 2) PRRP amplitude is significantly reduced in patients with low tension glaucoma (a cross-sectional study) and 3) normal physiological aging produces progressive reductions in PRRP amplitude (a cross-sectional study).