Design and engineering of proteins for biotechnology and biomedicine

这一应用的主要目的是通过重新设计和工程来提高蛋白质的热力学和折叠性能。重新设计的蛋白质的结构和折叠行为将使用X射线结晶学和生物物理技术进行表征。该项目的预期成果是：设计可用于生物技术、医疗和制药应用或基础研究的新蛋白质；对蛋白质设计和工程的基本见解；以及关于决定蛋白质稳定性和折叠的因素的丰富知识。

The primary aim of this application is to enhance the thermodynamic and folding properties of proteins by redesign and engineering. The structures and folding behaviour of the redesigned proteins will be characterised using X-ray crystallography and biophysical techniques. The expected outcomes of this project are: engineering of new proteins that can be used in biotechnology, medical and pharmaceutical applications, or basic research; fundamental insights into protein design and engineering; and a wealth of knowledge on the factors that dictate protein stability and folding.