3'UTR switching in eukaryotic cells

该项目旨在揭示转录后基因表达控制机制和功能的基本保守特征。RNA系统连接DNA的执行功能和蛋白质的工作功能。mRNA通常决定蛋白质合成的水平、时间和位置。该项目将使用rna测序和定制生物信息学来探测全球rna动力学。将酵母遗传学与rna技术相结合，重点研究真核细胞生物学中的3 '非翻译区（UTR）动力学。该项目预计将显著推进真核基因功能和基因调控的理解，在个性化基因组医学的时代至关重要。

The project aims to uncover conserved features fundamental to the mechanism and function of post-transcriptional gene-expression control. RNA systems interface the executive functions of DNA and the worker functions of proteins. mRNA often dictates the level, timing and location of protein synthesis. This project will use RNA-sequencing and bespoke bioinformatics to probe global RNA-dynamics. Mixing yeast-genetics with RNA-technologies, it focuses on 3’ untranslated region (UTR) dynamics in eukaryotic cell biology. This project expects to significantly advance the understanding of eukaryotic gene function and gene regulation, critical in an age of personalised genomic medicine.