Heparan sulphate mimetics: Versatile tools for chemical biology

该项目旨在开发化学工具来研究硫酸乙酰肝素结合蛋白。硫酸乙酰肝素是一种复杂的多糖，其在哺乳动物细胞上广泛表达，并与蛋白质相互作用以介导许多生物学和病理学功能。人们对这些相互作用知之甚少。该项目将使用同质的，结构确定的化合物来研究硫酸乙酰肝素及其生物学结合伙伴。预计这将导致对这些基本过程的更好的分子水平的理解，并可能在生物技术和药物开发中有未来的应用。

This project aims to develop chemical tools to study heparan sulphate-binding proteins. Heparan sulphate is a complex polysaccharide that is ubiquitously expressed on mammalian cells and interacts with proteins to mediate numerous biological and pathological functions. These interactions are poorly understood. This project will use homogeneous, structurally defined compounds to study heparan sulphate and its binding partners in biology. This is expected to lead to a better, molecular-level understanding of these fundamental processes, and may have future applications in biotechnology and drug development.