SYNTHESIS OF UNUSUAL BIOLOGICALLY ACTIVE TERPENES

在这项建议中，特别关注了全合成 五种结构独特的萜类天然产品。其中两个， 已知的截胸菌素和蛇绿素F具有非常可敬的 分别具有抗菌性能和抗真菌性能。吲哚青素是一种 二萜，其中几种酯已被报道显示出肿瘤 促进或抗白血病活性取决于它们的性质。总计 在制备精选酯的同时，合成吲哚酚， 在描述结构特征方面可能有实质性的价值 管理生物活动中最令人着迷的分裂。其他合成材料 目标包括斯特普酸，一种新型的倍半萜，它是 负责各种水果和装饰品中的“银叶病” 树和化学防御剂3β-羟基-7β-坎普-8(9)-烯-6-酮 新生的白蚁士兵蚂蚁。后两者的生物活性 尚未发现的物质及其新颖的结构特征 建议进行大范围的检测。这是我们希望的 用我们的合成材料来实现。

In this proposal, specific attention is given to the total synthesis of five uniquely structured terponoid natural products. Two of these, pleuromutilin and ophiobolin F are known to possess very respectable antibiotic and antifungal properties, respectively. Ingenol is a diterpene, several esters of which have been reported to exhibit tumor promotion or anti-leukemic activity depending on their nature. A total synthesis of ingenol, in tandem with the preparation of select esters, could be of substantive value in delineating the structural features which govern this most fascinating split in biological activity. Other synthetic targets include sterpuric acid, a new type of sesquiterpenoid which is responsible for "silver leaf disease" in various fruit and decorative trees, and 3Beta-hydroxy-7Beta-kemp-8(9)-en-6-one, a chemical defense agent of nasute termite soldier ants. The biological activity of the latter two substances has not been explored at all and their novel structural features suggest that broad-screened assays should be carried out. This we hope to achieve with our synthetic material.