ACYCLIC STEREOSELECTION

定义亲核试剂在与亲核试剂加成时所遵循的轨道 具有相邻手性中心的π-体系具有直接的应用（1） 旨在实现最大不对称的有机合成策略， 诱导，和（2）在理解的高立体特异性 伴随着前手性中心向手性中心的转化， 酶促反应 一个简单的理论模型，现在初步 发展，将扩大到占有吸引力的电子 控制立体化学的术语。 提出了一个实验方案， 验证这个模型的预测。 无环立体选择 通过碳-碳键形成反应表现出来，例如添加到 羰基，羟醛缩合，和共轭加成到α， β-不饱和系统，将进行研究。

Definition of the trajectory followed by a nucleophile in its addition to a Pi-system with an adjacent chiral center has immediate application (1) toward organic synthetic strategies aimed at achieving maximum asymmetric induction, and (2) in the understanding of the high stereospecificity accompanying the conversion of prochiral centers to chiral centers in enzymatic reactions. A simple theoretical model, now in initial development, will be expanded to account for the attractive electronic terms controlling stereochemistry. An experimental program is proposed to verify the predictions of this model. The acyclic stereoselection exhibited by carbon-carbon bond forming reactions, such as additions to carbonyl groups, aldol condensations, and conjugate additions to Alpha, Beta-unsaturated systems, will be studied.