STRATEGY FOR THE CHARACTERIZATION OF THE HUMAN GENOME

该程序涉及序列的检测和分析 人类基因组中的变异，特别是那些负责遗传 疾病或用于遵循这些变体。 我们将主要依靠 Fischer和Lerman的序列定义DNA分离系统， 扩展系统，无论是在其实验能力和理论 其功能的基础。 我们还将寻求一些结构性和 热力学问题，特别是那些与关系有关的问题 序列和螺旋相对于解链的稳定性之间。

The program is concerned with the detection and analysis of sequence variations in the human genome, particularly those responsible for genetic disease or useful in following those variants. We will depend largely on the system of sequence-defined DNA separations of Fischer and Lerman and extend the system, both in its experimental capability and in theoretical basis of its function. We will also pursue certain structural and thermodynamic questions, particularly those bearing on the relations between sequence and the stability of the helix with respect to melting.