CO-ADAPT: Adaptive management of endemic coinfections in ruminant livestock under climate change

牲畜通常被许多不同种类的寄生虫感染（称为共感染），但寄生虫控制通常侧重于一个物种或有限的相关物种群。COADAPT的核心目标是通过提高预测、测量和瞄准该领域共感染的能力，并为开发和应用提供工具，从而提高英国农业的竞争力和可持续性，并加强在寄生虫控制预测生物学和数字决策支持工具方面的国际领先能力，从而实现影响。我们将重点放在放牧反刍动物的寄生虫和胃肠道共感染上，因为它们普遍常见，经常限制生产，并且经常不适当地针对。季节性感染模式的变化和抗寄生虫药物耐药性的增加，对今后管理对生产、排放和动物福利的影响的能力造成重大限制。关键的挑战是能够自适应地管理合并感染，根据感染状况和影响准确地校准干预措施，使用有限的化学投入来获得最佳反应。这将需要与当前的风险保持一致，并有效地支持农场决策。

Livestock are commonly infected by many different species of parasite (termed coinfections), and yet parasite control generally focuses on one species or a limited group of related species. The core goal of COADAPT is to achieve impact by improving ability to predict, measure and target coinfections in the field, and supply tools for exploitation and application - to enhance the competitiveness and sustainability of the UK farming industry and to reinforce internationally leading capabilities in predictive biology and digital decision support tools for parasite control. We focus on parasitic and gastrointestinal coinfections in grazing ruminants because they are universally common, frequently production-limiting, and often inappropriately targeted. Changes in seasonal patterns of infection and increasing antiparasitic drug resistance impose major limitations on future ability to manage impacts on production, emissions and animal welfare. The key challenge is to be able to manage coinfections adaptively, calibrating interventions accurately to infection status and impact, using limited chemical inputs to obtain the best response. This will require alignment with prevailing risks, and effective support of on-farm decisions.