FREE-RADICAL MEDIATED ANNULATIONS AND ADDITIONS

基于自由基介导的[3+2]亚甲基环戊烷的发现， 未活化和富电子烯烃的环化， 2-苯磺酰基亚甲基-环丙烷，该提案旨在开发新的 自由基介导的成环和加成反应。为此， 初步目标将是开发一系列[3+2]环 允许未活化和未活化的亚甲基环戊烷环化的试剂， 富电子烯烃和一类新的亚甲基环戊烷成环反应 贫电子烯烃的混合物。另一个目标是开发新的 使用α-磺酰基自由基的未活化烯烃的反应。最终 目的是首次开发催化方法， 控制某些基团的绝对和相对立体化学 循环该项目的健康相关性源于其影响 关于合成各种各样的医学上重要的 天然和人工物质。

Based on the discovery of the radical mediated [3+2] methylenecyclopentane annulation of unactivated and electron-rich olefins with 2-phenylsulfonylmethylene-cyclopropanes, this proposal aims to develop new free-radical mediated annulation and addition reactions. Toward that end, the initial objective will be to develop a series of [3+2] annulation reagents allowing the methylenecyclopentane annulation of unactivated and electron-rich olefins, and a new class of methylenecyclopentane annulations of electron-poor olefins. Another objective is to develop new addition reactions of unactivated olefins using alpha-sulfonyl radicals. A final objective is to develop, for the first time, methods for the catalytic control of the absolute and relative stereochemistry of some radical cyclizations. The health relatedness of the project derives from its impact on methods for the synthesis of a wide variety of medicinally important natural and artificial substances.