SEX CHROMOSOMAL ABNORMALITIES: A PROSPECTIVE STUDY

这项研究的长期目标是继续建立 一组带有性染色体个体的发育历程 出生时以公正的方式鉴定的非整倍体。六十八 通过检查40,371名受试者的性染色质状态确定了他们的身份 1964年至1974年在丹佛的两家医院连续分娩。其中46% 自从他们出生以来，他们的家人就一直在跟踪他们。 这项家庭发展研究。只要有可能，兄弟姐妹就被用作 控制。最初的计划要么是在青春期后期，要么是 成年初期。性别认同、性活动和生殖活动； 对成人生活的适应将被记录在案。神经肌肉， 神经心理学、精神病学和内分泌评估将 特别强调。命题之间相互作用的性质， 他们的家人和同龄人将被记录在案。

The long-term objectives of this study are to continue to establish the developmental course of a group of individuals with sex chromosome aneuploidy identified at birth in an unbiased fashion. Sixty-eight propositi were identified by checking the sex chromatin status of 40,371 consecutive births in two Denver hospitals from 1964 to 1974. Forty-six of these have been followed with their families prospectively since birth in this Family Development Study. Wherever possible, siblings are used as controls. The original propositi will be either in late adolescence or early adult-hood. Gender identity, sexual and reproductive activity, and adaptation to adult life will be documented. Neuromuscular, neuropsychological, psychiatric, and endocrine evaluation will be particularly emphasized. The nature of the interaction between propositi, their families, and their peers will be documented.