Industrial Doctorate Centre: Bioprocessing Engineering Leadership

研究培训的广泛主题涉及以生物为中心的制药和医疗保健生物技术行业发展最快的部分。它满足行业主导的bioProcessUK和英国制药工业协会定义的特定培训需求。该中心的建议符合EPSRC交付计划2008/9至2010/11，其中指出制药作为英国最具活力的行业之一。EPSRC下一代医疗保健主题是将适当的工程和物理科学研究与医疗保健合作伙伴的工作联系起来，以改善将研究成果转化为临床产品和服务的工作。我们直接解决这个问题。生物制药部门由三个部分组成，该中心将致力于：-利用生物催化与化学相结合生产更具选择性的小分子药物;-生物制药治疗蛋白质和疫苗;-人类细胞疗法。在每一个情况下，由于广泛使用分子工程来提高临床效果，现在都提出了新的生物加工挑战，拟议的培训将解决新的挑战。尽管制药业是英国研究最为密集的行业之一，但由于以下原因，制药业正处于紧张的压力之下：-来自低成本国家的全球竞争日益加剧;-越来越复杂的药物越来越难以通过，其中许多药物的生产过程更加困难; -政府通过放宽仿制药的进入和降低药物报销水平来降低价格的压力。这些发展需要不断创新，工业博士培训中心将致力于生物加工方面的智力发展和严格培训。该活动将与EPSRC生物加工创新制造研究中心一起进行，该中心的国际审查得出结论，该中心引领世界进入一个日益重要的领域。

The broad theme of the research training addresses the most rapidly developing parts of the bio-centred pharmaceutical and healthcare biotech industry. It meets specific training needs defined by the industry-led bioProcessUK and the Association of British Pharmaceutical Industry. The Centre proposal aligns with the EPSRC Delivery Plan 2008/9 to 2010/11, which notes pharmaceuticals as one of the UK's most dynamic industries. The EPSRC Next-Generation Healthcare theme is to link appropriate engineering and physical science research to the work of healthcare partners for improved translation of research output into clinical products and services. We address this directly. The bio-centred pharmaceutical sector is composed of three parts which the Centre will address:- More selective small molecule drugs produced using biocatalysis integrated with chemistry;- Biopharmaceutical therapeutic proteins and vaccines;- Human cell-based therapies.In each case new bioprocessing challenges are now being posed by the use of extensive molecular engineering to enhance the clinical outcome and the training proposed addresses the new challenges. Though one of the UK's most research intensive industries, pharmaceuticals is under intense strain due to:- Increasing global competition from lower cost countries;- The greater difficulty of bringing through increasingly complex medicines, for many of which the process of production is more difficult; - Pressure by governments to reduce the price paid by easing entry of generic copies and reducing drug reimbursement levels. These developments demand constant innovation and the Industrial Doctorate Training Centre will address the intellectual development and rigorous training of those who will lead on bioprocessing aspects. The activity will be conducted alongside the EPSRC Innovative Manufacturing Research Centre for Bioprocessing which an international review concluded leads the world in its approach to an increasingly important area .