CONTROL OF ADH SECRETION AND METABOLISM

众所周知，加压素(ADH)在高血压中起重要作用。 体液的体积和成分的调节。现在就是 似乎ADH在正常和病理生理上也很重要 调节动脉压。拟议中的研究涉及到 血浆ADH浓度的控制及针对性处理 影响ADH进入血液和清除ADH的因素 通过肾脏和肝脏从血液中提取。关于ADH的控制 分泌我们将确定：1)ADH和催产素的中枢作用 基础状态下血浆ADH浓度的变化及其对机体的影响 出血；2)中枢作用的去甲肾上腺素、乙酰胆碱、 多巴胺、GABA、前列腺素、缓激肽、血管紧张素II和脑啡肽 在正常和病理生理控制下ADH的释放。关于 到拟议研究的第二个主要领域，ADH从 在循环中，我们将识别和评估影响循环的因素 ADH的肾脏和内脏清除。透彻了解 控制血浆ADH浓度的因素应该是有价值的 在临床上处理高血压和涉及 水和电解质代谢紊乱，例如充血心脏 失败了。

It is well established that vasopressin (ADH) is important in the regulation of the volume and composition of the body fluids. It now appears that ADH is also important in the normal and pathophysiological regulation of arterial pressure. The proposed research is concerned with the control of the plasma ADH concentration and deals specifically with factors affecting secretion of ADH into the blood and the clearance of ADH from the blood by the kidneys and liver. With regard to the control of ADH secretion we shall determine: 1) the central actions of ADH and oxytocin on the plasma ADH concentration under basal conditions and in response to hemorrhage; 2) the role of centrally acting norephinephrine, acetylcholine, dopamine, GABA, prostaglandins, bradykinin, angiotensin II, and enkephalin in the normal and pathophysiological control of ADH release. With regard to the second major area of proposed research, the clearance of ADH from the circulation, we shall identify and evaluate factors which affect the renal and splanchnic clearances of ADH. A thorough understanding of the factors that control the plasma ADH concentration should be of value clinically in dealing with hypertension and with diseases that involve derangements of water and electrolyte metabolism, e.g., congestive heart failure.