KALLIKREIN-KININ SYSTEM IN HYPERTENSION

新的数据为这一假说提供了额外的支持 (和腺体)激肽释放酶-激肽系统参与电解质 动态平衡、肾功能和体动脉压的控制。 这些数据包括：尿激肽释放酶、血液之间的进一步相关性 正常或高血压儿童的压力、种族和其他变量 父子关系；有关系统组件和正常活动的更多信息 受试者，患有高血压和其他疾病的患者，以及在某些情况下 动物模型；新发现的系统与其他系统之间的关系 对肾脏和心血管动态平衡事件、药物和 膜离子传输.附加组织化学和生化数据 系统部件国产化和监管；以及在以下方面的重大进展 测量技术。这项研究将探索两者之间的关系 激肽释放酶-激动素系统、膜离子转运、醛固酮与全身 血压。我们将研究：调节激肽释放酶的因素 合成和活性；该系统在膜离子转运中的作用； 改变肾上腺/肾脏的药物、生物化学物质和疾病的影响 功能和/或血压对系统的影响，反之亦然 改变系统活动对电解质运输、排泄和血液的影响 压力。活性和非活性激肽释放酶、激肽和激肽原将 用放射免疫法、放射化学法、分光光度法和 生物检测。环氧合酶级联的部分成分，环状 核苷酸和钙将在研究中测量，旨在检查 激肽释放酶和激肽释放酶功能反应相关的生化事件 金宁。正常志愿者、高血压及其他疾病患者 以及分离的组织和细胞将被研究。我们的目标是： 1)继续界定调节组织活动的因素 腺(肾)激肽释放酶-激肽释放酶系统；2)继续描述 腺(肾)激肽释放酶-激肽系统的功能；3)继续 评估该系统在高血压疾病中的作用；以及4) 了解激肽释放酶-醛固酮的作用机制 两性关系。

New data are providing additional support for the hypothesis that the renal (and glandular) kallikrein-kinin system is involved in electrolyte homeostasis, renal function and the control of systemic arterial pressure. The data include: further correlations amongst urinary kallikrein, blood pressure, race, and other variables in children of normal or hypertensive parentage; more information about system components and activity in normal subjects, patients with hypertensive and other diseases, and in certain animal models; newly discovered relations between the system, other systems important to renal and cardiovascular homeostatic events, drugs and membrane ion transport; additional histochemical and biochemical data on system component localization and regulation; and major advances in measurement technology. The research will explore relations amongst the kallikrein-kinin system, membrane ion transport, aldosterone and systemic blood pressure. We shall examine: factors which regulate kallikrein synthesis and activity; the role of the system in membrane ion transport; the effects of drugs, biochemicals and disease which alter adrenal/renal function and/or blood pressure upon the system, and conversely, the effects of altered system activity upon electrolyte transport, excretion and blood pressure. Active and inactive kallikreins, kinins and kininogens will be measured with radioimmuno-, radio-chemical, spectrophotometric and bioassays. Selected components of the cyclooxygenase cascade, cyclic nucleotides and calcium will be measured in studies designed to examine the biochemical events related to the functional responses to kallikrein and kinins. Normal volunteers, patients with hypertensive and other diseases as well as isolated tissues and cells will be studied. Our objecties are: 1) to continue to define factors which regulate the activity of the glandular (renal) kallikrein-kinin system; 2) to continue to describe the function of the glandular (renal) kallikrein-kinin system; 3) to continue to assess the role of the system in hypertensive diseases; and 4) to understand the mechanisms responsible for the kallikrein-aldosterone relationship.