CONTROL OF ADH SECRETION AND METABOLISM

加压素在控制肾水排出中的作用由来已久。 已经为人所知。近年来发展的证据表明，加压素 可能在心血管的生理控制中也很重要 系统，这些一直是相当感兴趣的可能性 加压素参与某些形式的临床高血压病的发病机制 和实验性高血压。这是我们的长期目标。 研究计划，以确定和研究决定 血浆加压素浓度。本申请涉及 大脑神经递质和神经调节剂的作用涉及 血浆渗透压升高对加压素释放的刺激作用 通过降低血容量和血压。大脑中的前列腺素似乎 在渗透压和体积压控制中起着重要作用 后叶加压素的释放，通过调节相关的 神经递质或通过直接作用于加压素能 神经分泌细胞。建议对这一假设进行检验，并 确定参与这一控制的大脑神经递质和部位 在发生这些动作的大脑中。

The role of vasopressin in the control of renal water excretion has long been known. Evidence developed in recent years suggests that vasopressin may also be important in the physiological control of the cardiovascular system, and these has been considerable interest in the possible participation of vasopressin in the pathogenesis of some forms of clinical and experimental hypertension. It has been the long-term objective of this research program to identify and study the factors which determine the plasma concentration of vasopressin. The present application is concerned with the role of brain neurotransmitters and neuromodulators involved in the stimulation of vasopressin release by increased plasma osmolality and by decreased blood volume and blood pressure. Brain prostanoids appear to play an important role in the osmotic and volume-pressure control of vasopressin release, by modulating the activity of the relevant neurotransmitters or by direct actions on the vasopressinergic neurosecretory cells. It is proposed to test this hypothesis and to identify the brain neurotransmitters involved in this control and the sites in the brain where these actions occur.