Mitochondrial biogenesis in mammalian cells

该项目旨在了解参与线粒体蛋白质生物发生的分子机器的内部工作原理。线粒体是提供大部分细胞能量的重要细胞器。细胞器的发生依赖于组成细胞器的蛋白质和脂类的协调合成和运输。该项目计划定义分子机器的体系结构，概述其组件如何发挥功能，并探索蛋白质和脂质在线粒体发生中的关系。这些结果有望提供有关线粒体生成如何受到调控的知识。

This project aims to understand the inner workings of a molecular machine involved in mitochondrial protein biogenesis. Mitochondria are essential organelles that provide the bulk of cellular energy. Genesis of the organelle relies on the coordinated synthesis and transport of both proteins and lipids that make up the organelle. This project plans to define the architecture of the molecular machine, outline how its components function, and explore the relationship between proteins and lipids in mitochondrial genesis. These results are expected to provide knowledge about how mitochondrial creation is regulated.