CONTROL OF ADH SECRETION AND METABOLISM

血管加压素在控制肾水排泄中的作用已经很长时间了。 已知的。 近年来的证据表明，加压素 可能在心血管疾病的生理控制中也很重要， 系统，这些都是相当大的兴趣，在可能的 加压素参与某些临床形式的发病机制 实验性高血压 这是我们的长期目标 研究计划，以确定和研究的因素，决定 加压素的血浆浓度。 本申请涉及 大脑神经递质和神经调质的作用 通过增加血浆渗透压刺激加压素释放， 通过减少血容量和血压。 脑前列腺素类似乎 在渗透压和体积压控制中起重要作用， 加压素释放，通过调节相关的 神经递质或通过直接作用于加压素能 神经分泌细胞 有人建议检验这一假设，并 确定参与这种控制的大脑神经递质和 大脑中发生这些行为的地方。

The role of vasopressin in the control of renal water excretion has long been known. Evidence developed in recent years suggests that vasopressin may also be important in the physiological control of the cardiovascular system, and these has been considerable interest in the possible participation of vasopressin in the pathogenesis of some forms of clinical and experimental hypertension. It has been the long-term objective of this research program to identify and study the factors which determine the plasma concentration of vasopressin. The present application is concerned with the role of brain neurotransmitters and neuromodulators involved in the stimulation of vasopressin release by increased plasma osmolality and by decreased blood volume and blood pressure. Brain prostanoids appear to play an important role in the osmotic and volume-pressure control of vasopressin release, by modulating the activity of the relevant neurotransmitters or by direct actions on the vasopressinergic neurosecretory cells. It is proposed to test this hypothesis and to identify the brain neurotransmitters involved in this control and the sites in the brain where these actions occur.