ULTRASONIC INSTRUMENTATION FOR CARDIOVASCULAR STUDIES

该项目的目标是开发、评估和利用几个 超声技术在血流、心功能测量中的应用 和力学，以及急性和慢性的血管尺寸 心血管疾病的仪器化动物模型 诊断和治疗冠状动脉疾病，并在患者 正在进行微血管重建。具体项目有：1) 继续发展单晶多谱勒位移 通过增加量程门测量心肌增厚的技术 追踪器跟踪任何所需的层。这和原来的非跟踪 设备将根据运输时间法使用导线和 海绵靶标在急性心肌和缺血心肌的体外及正常和缺血心肌中的作用 长期使用仪器的狗。2)利用多普勒位移法 一种测定跨壁区域变异的仪器 心肌增厚在正常和缺血心肌中的分布 在动物和心脏手术期间的患者中。3)轻松开发 可拆卸式脉冲多普勒探头监测重建血管通畅性 术后微血管修复。4)发展一种小的、高的 使用高频(10或20 MHz)的分辨率血管直径传感器 渡越时间晶体或高频(20 MHz)多普勒位移 用于正在进行的血管运动研究的探头，影响因素 移植静脉的动脉生长、动脉化和局部反应 血管扩张剂。5)研制微型(1 Mm)单晶脉冲回波 导管从动脉内感觉动脉壁厚度(和成分) 用于计划和评估气囊和激光扩张的血管 血管成形术。6)开发微型(1 Mm)20 MHz脉冲 带有导丝管腔的多普勒导管，用于检测血流速度 冠脉病变时冠脉内的亚选择性分布 动脉造影术和血管成形术。应用程序包括 通过离散方法评估血管储备(充血反应) 在诊断过程中的损害和评估的效果 血管成形术对血流和血管储备的影响。

The goal of this project is to develop, evaluate, and utilize several ultrasonic techniques in the measurement of blood flow, cardiac function and mechanics, and vascular dimensions in acute and chronically instrumented animal models of cardiovascular disease, in patients being diagnosed and treated for coronary artery disease, and in patients undergoing microvascular reconstruction. The specific projects are: 1) Continue the development of the single crystal Doppler displacement technique for measuring myocardial thickening by adding a range gate tracker to follow any desired layer. This and the original non-tracking device will be evaluated against the transit-time method using wire and sponge targets in-vitro and in normal and ischemic myocardium in acute and chronically instrumented dogs. 2) Utilize the Doppler displacement instrument to determine the regional variations in the transmural distribution of thickening in normal and ischemic myocardium both in animals and in patients during cardiac surgery. 3) Develop an easily removable pulsed Doppler probe to monitor the patency of reconstructive microvascular repairs post-operatively. 4) Develop a small, high resolution vessel diameter sensor using high frequency (10 or 20 MHz) transit-time crystals or a high frequency (20 MHz) Doppler displacement probe to be utilized in ongoing studies of vasomotion, factors affecting arterial growth, arteriolization of vein grafts, and regional responses to vasodilators. 5) Develop a miniature (1 mm), single-crystal pulse-echo catheter to sense arterial wall thickness (and composition) from within the vessel to be used to plan and assess dilatation with balloon and laser angioplasty procedures. 6) Develop a miniature (1 mm) 20 MHz pulsed Doppler catheter with a guide wire lumen for sensing flow velocity subselectively in the coronary arteries of man during coronary arteriography and angioplasty procedures. Applications include the assessment of vascular reserve (hyperemic response) through discrete lesions during diagnostic procedures and the evaluation of the effects of angioplasty on flow and vascular reserve.