CONTROL CARDIOVASCULAR AND RENAL EFFECTS OF POTASSIUM

在过去的五年里，我一直致力于分析控制系统， 调节钾。 这一分析将继续下去，其职能是： 在统一条件下分别分析不同组分， 数据可以被合并。 控制系统的数学模型 已开发并将扩展用于开发和测试 假设 短期钾调节的重要因素将是 实验研究包括：1）β-肾上腺素能系统的影响 2）钾素调控系统与植物的相互作用; 胰岛素-葡萄糖控制系统，3）血浆K和 血管紧张素II在醛固酮调节，4）和时间过程的作用， 影响钾分配和排泄的因素。 血浆钾及钾平衡改变对肾功能及预后影响的分析 心血管功能将继续。 以下领域将是 研究：持续的K变化对1）泵送能力的影响 心脏，2）循环的神经控制，3）血管平滑的控制 肌肉，4）肾功能，5）血压调节，6）渗透压 调节，和7）葡萄糖调节。 目前，对K调节只有初步的了解， 钾浓度异常对主要器官系统的影响。 的 本报告所建议项目的结果将提供信息， 了解这些领域，这将改善管理， 国家的部分医疗保健问题，包括心脏病， 高血压、糖尿病、手术压力和多种疾病 与老年有关。

For the last five years I have worked to analyze the control system that regulates potassium. This analysis will continue, with the functions of the different components analyzed separately under uniform conditions so that the data may be combined. A mathematical model of the control system has been developed and will be expanded for use in developing and testing hypotheses. Factors important in short-term potassium regulation will be studied experimentally including: 1) effects of the Beta-adrenergic system on K regulation, 2) interaction between the K control system and the insulin-glucose control system, 3) interactions between plasma K and angiotensin II in aldo-sterone regulation, 4) and time courses of action of factors affecting K distribution and excretion. The analysis of effects of changes in plasma K and K balance on renal and cardiovascular function will continue. The following areas will be studied: effects of sustained changes in K on 1) pumping ability of the heart, 2) neural control of the circulation, 3) control of vascular smooth muscle, 4) renal function, 5) blood pressure regulation, 6) osmotic regulation, and 7) glucose regulation. Currently, there is only a rudimentary understanding of K regulation and the effects of abnormal K concentration on the major organ systems. The results of the projects proposed herein will provide information and understanding in these areas which will improve management of a large portion of the health care problems of the nation, including heart disease, hypertension, diabetes mellitus, surgical stress and numerous conditions associated with old age.