CHARACTERIZATION OF LEFT VENTRICULAR DIASTOLIC FUNCTION

左室心舒张特性将以下列方面为特征 舒张期早期松弛、舒张压-体积和应力-应变 高血压性心脏病患者左心室充盈的关系及模式 冠状动脉疾病和正常受试者。舒张期功能将会是 利用同时记录的左心室血管造影术进行测定 在心脏诊断过程中的体积和高保真压力 使用压力计顶端导管进行插管，并对两种方法进行评估 根据可用的表达式以及新开发和/或修改的 算法。左心室容量将非侵入性地通过 放射性核素技术。非侵入性获取的压力-体积分析 然后与通过对比确定的值相关联 脑室造影术。此外，舒张期的扩张性也将 以脑室充盈率为特征。脑室 压力也将从一阶和二阶导数计算出来 心肌放射性核素时间活度曲线。舒张期特性 也将通过使用傅里叶快速变换进行相位分析来检查 脑室充盈不均匀的检测及其与病变的关系 舒张期功能。缺血心肌再灌流对心肌的影响 左心室的节段性和整体舒张期特性 在接受冠脉溶栓治疗的犬身上进行评估 链激酶，以确定心肌僵硬是否增加 有助于明显保护心脏收缩功能。这个 心脏舒张期特性的病理生理决定因素将是 特别考虑到心外限制的作用而界定； 外周动、静脉循环动力学对心脏的影响 将使用前臂外部评估收缩和舒张期功能 体积描记术。正压和呼气压力的影响 通风对左心室收缩和舒张期行为的影响 使用插管和无创两种方法进行检查 (超声心动图)技术精选药理的影响 和生理影响-特别是指其药物 这些效应可能会进一步深入了解高血压的生理决定因素 舒张期特性--舒张期功能将被确定。

Left centricular diastolic properties will be characterized in terms of early diastolic relaxation, diastolic pressure-volume and stress-strain relations, and patterns of left ventricular filling in patients with coronary artery disease and normal subjects. Diastolic function will be determined utilizing simulataneously recorded left ventricular angiographic volumes and high fidelity pressures, during diagnostic cardiac catheterization with the use of manometer tip catheters, and evaluated both in terms of available expressions and newly developed and/or modified algorithms. Left ventricular volumes will be determined non-invasively by radionuclide techniques. Pressure-volume analysis acquired non-invasively will then be correlated with that determined from contrast ventriculograms. In addition, diastolic distensile properties will also be characterized in terms of the ventricular filling rate. Ventricular pressures will also be computed from the first and second derivatives of the ventricular radionuclide time activity curve. Diastolic properties will also be examined by phase analysis using the Fourier fast transform to detect inhomogeneity of ventricular filling and its relation to altered diastolic function. The influence of reperfusion of ischemic myocardium upon left ventricular segmental and global diastolic properties will be evaluated in dogs which have undergone coronary thrombolysis with streptokinase, to determine whether increased myocardial stiffness contributes to the apparent preservation of systolic function. The patho-physiologic determinants of ventricular diastolic properties will be defined with particular regard to the role of extracardiac constraints; the role of peripheral arterial and venous circulatory dynamics upon cardiac systolic and diastolic function will be evaluated using external forearm plethysmography. The influence of positive and expiratory pressure ventilation upon left ventricular systolic and diastolic behavior will be investigated using both catheterization and non-invasive (echocardiographic) techniques. The influence of selected pharmacologic and physiologic influences - with particular reference to drugs whose effects may yield further insight into the physiological determinants of diastolic properties-on diastolic function will be determined.