ORGANIZATION OF CENTRAL SYMPATHETIC SYSTEM

中枢神经系统在外周调节中的作用 对正常血压和高血压患者的血流动力学进行了广泛的研究。 主题，但这项工作主要是从全球运营进行的 观点(投入产出关系)。人们对此知之甚少 涉及到的特定中枢神经系统回路。众所周知的现实，如 交感神经张力、压力感受器反射、中枢压力感受器重置 (药物诱导或其他原因)，“血管运动中枢”，到目前为止还非常 神经生理学底物不精确。即使是最基本的髓质 环路，包括投射到交感神经的通路 节前神经元，我们知之甚少。建议的目标是 研究目的是建立合理的髓内通路模型 参与控制交感神经流出和流入的水平 产生基本的交感音调。我们在该地区的长期利益 血压调节的病理学是选择大鼠作为 实验对象因为提供了独特的研究机会 通过在该物种中研究得很好的高血压模型的可用性。 拟议中的调查的起点是神经生理学 前腹外侧网状结构的研究 压倒性的证据表明，这一地区对于维护 压力感受器反射操作和继电保护中的交感音 由于高级结构的活动而产生的交感神经兴奋。这项建议 也是基于我们的初步结果，这些结果表明这个地区 可能确实含有交感前运动神经元(投射到胸部 交感神经核)控制交感神经流出到 脉管系统。因此，很大一部分工作将致力于 了解这些神经元在产生交感神经张力中的作用 以及它们对压力感受器和其他交感反射的贡献。这个 这些细胞使用的神经递质的性质也将是 调查过了。研究的第二部分将致力于传入 这些细胞的输入，更具体地说，是那些传达其 强大的压力感受器抑制。最后，我们将尝试 从神经生理学的角度理解人类模型的病理学 高血压，自发性高血压大鼠。 这项工作代表了我们之前的研究的延伸，它更多地 专门针对理解中心的作用 中枢自主神经调节中的单胺能通路。

The role of the central nervous system in regulating peripheral haemodynamics has been studied extensively in normotensive and hypertensive subjects but this work has been mostly conducted from a global operational point of view (input-output relationships). Rather little is known about the specific CNS circuits involved. Such well known realities as the sympathetic tone, baroreceptor reflexes, central baroreceptor resetting (drug-induced or otherwise), the "vasomotor center", have as yet very imprecise neurophysiological substrates. Even the most basic medullary circuits, including the pathways projecting to the sympathetic preganglionic neurons, are very poorly known. The goal of the proposed research is to establish a reasonable model of the medullary pathways involved in controlling the level of the sympathetic outflow and in generating the basal sympathetic tone. Our long-term interest in the pathology of blood pressure regulation is the reason for chosing the rat as experimental subject because of the unique research opportunities presented by the availability of well-studied models of hypertension in this species. The starting point of the proposed investigation is a neurophysiological study of the anterior ventrolateral reticular formation since there is now overwhelming evidence that this area is essential in the maintenance of the sympathetic tone, in the operation of baroreceptor reflexes and in relaying sympathoexcitation due to the activity of higher structures. The proposal is also predicated on our preliminary results which indicate that this area may indeed contain sympathetic premotorneurons (projecting to the thoracic sympathetic nucleus) controling the sympathetic outflow to the vasculature. A large part of the work will therefore be devoted to understanding the role of these neurons in generating the sympathetic tone and their contribution to baroreceptor and other sympathetic reflexes. The nature of the neurotransmitters used by these cells will also be investigated. A second part of the study will be devoted to the afferent inputs of these cells and more particularly to those which convey their powerful baroreceptor inhibition. Finally, an attempt will be made to understand in neurophysiological terms the pathology of a model of human essential hypertension, the SHR rat. This work represents an extension of our previous research which was more specifically targeted toward understanding the role of central monoaminergic pathways in central autonomic regulations.