TRANSLUMINAL ANGIOPLASTY CORONARY HEART DISEASE RESEARCH

动物研究的长期目标是开发新的技术 应用黄连治疗某些形式的先天性心脏病 经皮腔内血管成形术。更具体地说， 一项旨在评估导管球囊扩张治疗主动脉的工作 瓣膜狭窄，造成局限性的间隔缺陷，扩张狭窄 体肺分流。待评估的实验程序 可能通过提供新的非手术治疗而直接应用于临床 婴幼儿和青壮年先天性心脏病的治疗方法 心脏有问题。狗将被用于研究。血液动力学 将评估球囊闭塞主动脉流出道的效果。 在主动脉缩窄所致左心室肥厚的动物中。这个 腹主动脉环耐受不同程度高血压的能力 大直径球囊血管成形术导管引起的过度扩张 也将接受评估。固定直径导管气囊扩张术 还将在狗身上研究房间壁。风险和 固定式球囊房间隔缺损扩张术的疗效观察 手术将与目前的拉通术和/或刀片中隔造口术进行比较 程序。最后，患有外科手术的土生土长的狗和戈尔特克斯 将对体肺分流进行研究以评估形态学 分流管扩张和过度扩张的血管成形术结果。 临床经验表明，狭窄的肺-体分流术 对血管成形术的反应不如类似的狭窄 在髂骨和股骨区的分流。研究的结果应该是 提供了与潜在临床应用相关的重要数据 非手术、经皮球囊扩张术治疗 治疗先天性心脏病。这些研究也应该延长我们的 关于限制和潜在风险的最新知识：好处 这类程序的比率。

The long term goal of the animal research is to develop new techniques for treating some forms of congenital heart disease through the use of percutaneous transluminal angioplasty procedures. More specifically, the work is designed to evaluate catheter balloon dilatation to treat aortic valve stenosis, create localized septal defects, and dilate stenotic systemic-pulmonary shunts. The experimental procedures to be evaluated may have direct clinical application by providing new non-surgical approaches to treating infants and young adults suffering from congenital heart conditions. Dogs will be used for the studies. The hemodynamic effects of balloon occlusion of the aortic outflow tract will be evaluated in animals with aortic banding induced left ventricular hypertrophy. The ability of the aortic annulus to tolerate varying degrees of overdistension produced by large diameter balloon angioplastic catheters will also be evaluated. Fixed diameter catheter balloon dilatation of the interatrial wall will also be studied in dogs. The risks and effectiveness of the fixed balloon atrial septal defect dilatation procedure will be compared to current pull-through and/or blade septostomy procedures. Finally, dogs with surgically native and Gortex systemic-pulmonary shunts will be studied to evaluate morphological results of angioplasty dilatation and overdilatation of the shunts. Clinical experience indicates that stenotic pulmonary-systemic shunts do not respond to angioplasty procedures as successfully as similar stenotic shunts in the iliac and femoral region. Results of the studies should provide important data relating to the potential clinical application of non-surgical, percutaneous transcatheter balloon dilatation procedures for treating congenital heart disease. The studies should also extend our current knowledge regarding the limitations and potential risk:benefit ratio of such procedures.