THE IMMUNOLOGY OF THE VASCULAR ENDOTHELIUM IN VASCULITIS

在界定这一作用时，将审查两个广泛的调查领域 血管内皮细胞在免疫发病机制中的作用 血管炎 内皮细胞功能的实验模型将是 最终用这些模型来研究 血管炎的调节因子。 将研究内皮细胞， 其以各种方式调节免疫细胞功能的能力，例如 内皮细胞作为淋巴细胞辅助细胞的能力 激活和内皮细胞产生 免疫调节分子如白细胞介素-1。 特别是 通过免疫调节内皮细胞产生IL-1， 炎症介质以及来自血管炎患者血清的因子 细胞将被深入研究。 免疫细胞表达 还将研究内皮细胞的表面标志物， 与临床活性相关因素的关系和调节 血管炎 内皮细胞也将作为一个潜在的目标进行检查 针对血管炎的损伤， 血管紧张素-1-转化的内皮细胞质膜蛋白 酶和脂蛋白脂酶。 细胞介导的免疫对 内皮细胞和针对基底膜的细胞介导的免疫 还将研究胶原蛋白。 这些拟议中的实验可能会带来新的， 关于坏死性胰腺炎潜在免疫发病机制的令人兴奋的信息 血管炎 进一步了解血管损伤的机制， 血管炎应该导致一个更合理的方法来治疗 患有这种多种疾病的患者。

Two broad areas of investigation will be examined in delineating the role of the vascular endothelium in the potential immunopathogenesis of vasculitis. Experimental models of endothelial cell function will be established with the idea of eventually using such models to study regulatory factors in vasculitis. The endothelial cell will be studied for its ability to modulate immune cell function in various ways, such as the ability of endothelial cells to serve as accessory cells for lymphocyte activation and the capacity of endothelial cells to produce immunoregulatory molecules such as interleukin-1. In particular, the regulation of IL-1 production by endothelium cells by immune and inflammatory mediators, as well as factors from vasculitic patient's sera and cells will be studied in depth. The expression of immunological cell surface markers by endothelial cells will also be studied and their relationship to and modulation by factors related to clinically active vasculitis. Endothelial cells will also be examined as a potential target for injury in vasculitis by concentrating on the potential antigenicity of endothelial cell plasma membrane proteins such as angiotensin-1-converting enzyme and lipoprotein lipase. The role of cell mediated immunity to endothelial cells and cell mediated immunity directed to basement membrane collagen will also be studied. These proposed experiments may shed new and exciting information on the potential immunopathogenesis of necrotizing vasculitis. A better understanding of the mechanism of vascular injury in vasculitis should lead to a more rational approach to the therapy of patients with this widely varied disorder.