TECHNIQUES FOR CHARACTERIZATION OF ATHEROSCLEROTIC PLAQU

动脉粥样硬化斑块的特征将通过以下方法进行研究： 发展和使用方法的基础上分析反映 用垂直于动脉的声束获取的超声信号。 这些技术将有助于非阻流的检测 导致症状的斑块，以及在进展/消退的研究中， 人体内的斑块 要使用的信号测量是， 径向血流，血管尺寸，斑块回波幅度，斑块 衰减和基于倒频谱分析的血管壁结构。 在 此外，壁阻抗和损耗分布将通过使用 正在开发的精确反演方法。 将从体模中获得数据，用于设备校准，并作为 检查方法的准确性。 来自较老尸体的血管， 可见斑块将用于关联超声和病理学 调查结果。 选定的病人将在托马斯杰斐逊医院接受检查 大学医院血管实验室，以及与X射线和 按照建立的方案手术标本并用于B模式 评估联系工作。 数据将被数字化并存储在磁盘上， 在德雷克塞尔进行初步的离线分析，在一个系统上进行修改， 在诊所进行分析。

The characterization of atherosclerotic plaque will be investigated through the development and use of methods based on analysis of reflected ultrasonic signals taken with the sound beam perpendicular to the artery. These techniques will be useful in examination of non flow-obstructing plaque that causes symptoms, and in studies in progression/regression of plaque in humans. Signal measures to be used are, Doppler-shifted signals from radially-directed flow, vessel dimensions, plaque echo amplitude, plaque attenuation, and vessel wall structure based on cepstrum analysis. In addition, wall impedance and loss profiles will be obtained through use of exact inversion methods under development. Data will be obtained from phantoms for equipment calibration and as a check on accuracy of methods. Vessels from older cadavers containing visible plaque will be used to correlate ultrasound and pathology findings. Selected patients will be examined at Thomas Jefferson University Hospital Vascular Lab, and data correlated with x-ray and surgery specimens following protocols established and used for the B-mode assessment contact effort. Data will be digitized and stored on disk for initial off-line analysis at Drexel, on a system to be modified later to perform analysis in the clinic.