RISK FACTORS IN BRONCHOPULMONARY DYSPLASIA

建议进行一项全面的流行病学研究以进行调查 慢性支气管炎肺发育不良的危险因素 发生在早产儿身上的肺部疾病。在 第一年，这项研究旨在标准化诊断并开发一种 急慢性疾病严重程度评分系统 疾病的某些方面。 随后，将进行多因素调查，以 阐明BPD与急性肺病的关系 严重程度，呼吸相关变量，水平衡，营养， 家庭易感性、环境、妊娠和分娩 参数。研究中的重要特征是一致的 诊断标准、大样本量和前瞻性数据 收集。 所有出生时体重在1,501克以下的婴儿在六个新生儿重症监护室 威斯康星州的护理病房将被纳入这项研究。基线数据 所有这些都将提交标准化的医院日志 婴儿。对于存活7天的新生儿，产妇面谈将 被引导了。严重程度评分和诊断将基于 医院日志和常规X光检查。归根结底，我们会比较 患有BPD的婴儿与没有BPD的婴儿，对照 混杂因素，特别强调相互作用的影响。 此外，一组足月新生儿将作为一个整体 控制力。

A comprehensive epidemiologic study is proposed for investigating risk factors in Bronchopulmonary Dysplasia (BPD), a chronic pulmonary disease which occurs in premature neonates. In the first year, the study aims to standardize diagnosis and develop a scoring system for grading the severity of acute and chronic aspects of the disease. Subsequently, a multifactorial investigation will be undertaken to elucidate the relationship between BPD, acute lung disease severity, respiration related variables, water balance, nutrition, familial predisposition, environmental, pregnancy and delivery parameters. Important features in the study are uniform diagnostic criteria, large sample size and prospective data collection. All infants below 1,501 grams at birth in six neonatal intensive care units in Wisconsin will be entered in the study. Baseline data and standardized hospital logs will be submitted for all these infants. For neonates surviving 7 days, maternal interviews will be conducted. Severity scoring and diagnosis will be based on the hospital log and routine x-rays. Final analysis will compare infants with BPD to those without BPD, controlling for confounders and placing special emphasis on interaction effects. Additionally, a group of full term neonates will serve as an overall control.