EFFECTS OF NUTRIENTS IN HYPERTENSION

这项研究计划解决了这样一个假设，即饮食 成分对血压(BP)有显著影响， 一个主要的心血管危险因素，在亚组中 高血压。这是各方共同努力的结果 在循环控制、自主神经方面有专长的调查人员 功能，血小板功能，肠道运输， 生热和能量平衡，以及减肥。 项目I-假设：增加口服钙离子摄入量可降低血压 在高血压(HBP)患者中；这种改变 依赖于钠的摄入量。不同Ca~(++)和Ca~(2+)的影响 高血压病患者的Na+摄入量，按肾素分层 状态和Na+敏感性，将用多变量进行评估 分析变化可能产生的独立影响。 血清总、游离钙离子和甲状旁腺激素中的Na+。 我们将测定血小板内钙、钠、血小板功能 以及患者的外周血管反应性。肠道 自发性高血压病中钙离子的吸收与处理及红花中的钙离子转运 高血压患者的细胞幽灵。 项目二--假设：特别是甲基黄嘌呤 饮食中的咖啡因，对患有咖啡因的患者有有害影响 肾血管性高血压(RV HBP)。轮状病毒动物的研究 我们实验室的模型表明咖啡因会导致这样的 恶性高血压病伴发的血压严重升高。 肾静脉肾素、血管紧张素和腺苷的测定 安慰剂和甲基黄嘌呤在人体内的浓度 RV HBP患者将允许我们定义咖啡因是否 这种作用是通过促进肾素的释放来实现的 腺苷受体抑制。自发性高血压的联合研究将 定义Na+和咖啡因之间可能的相互作用。 咖啡因患者的双盲、安慰剂对照试验 RV HPB和肾素水平低升高的个体 将进行钠盐饮食。 项目III-假设：肥胖患者的饮食调整 高血压可能对血管有不同的影响 反应性和血压，取决于脂肪酸(FA) 减肥饮食的成分。慢性阻塞性肺疾病临床研究 将通过减肥饮食来改变血压 利用omega-6、omega-3和饱和脂肪酸。在病人中 接受omega-3脂肪酸，研究血小板功能和 这些脂肪酸的血小板掺入将有助于确定潜在的 对心血管风险的其他有益影响。研究 外周血管的反应性将在这些 举重开始和结束时的受试者 减免期。

This research program addresses the hypothesis that dietary constituents have a significant effect on blood pressure (BP), a major cardiovascular risk factor, in subgroups of hypertensives. It is a collaborative effort among investigators with expertise in circulatory control, autonomic function, platelet function, intestinal transport, thermogenesis and energy balance, and obesity modification. Project I - Hypothesis: Increasing oral Ca++ intake lowers BP in patients with essential hypertension (HBP); this alteration is dependent on sodium intake. The effect of varying Ca++ and Na+ intake in essential hypertensives, stratified by renin status and Na+ sensitivity, will be assessed with multivariate analysis of the possible independent effects of alterations in Na+ in serum total and ionized Ca++ and parathyroid hormone. We will determine intraplatelet Ca++, Na+, platelet function and peripheral vascular reactivity in patients. Intestinal Ca++ absorption and handling in SHR and Ca++ transport in red cell ghosts from hypertensive subjects. Project II - Hypothesis: Methylxanthines, particularly dietary caffeine, have a deleterious effect in patients with renovascular hypertension (RV HBP). Studies in a RV animal model in our laboratory suggest that caffeine causes such a serious increase in BP that malignant HBP supervenes. Determination of renal vein renin, angiotensin, and adenosine levels during infusions of placebo and methylxanthine in patients with RV HBP will allow us to define whether caffeine's effect is mediated by enhanced renin release as a result of its adenosine receptor inhibition. Allied studies in SHR will define possible interactions between Na+ and caffeine. Double-blind, placebo-controlled caffeine trials in patients with RV HPB and in individuals with renin levels raised by low sodium diets will be performed. Project III - Hypothesis: Dietary modification in obese hypertensives may have differential effects on vascular reactivity and BP, depending on the fatty acid (FA) constituents of the weight reduction diet. Clinical studies of BP modification by weight reduction diets will be done utilizing omega-6, omega-3, and saturated FAs. In patients receiving omega-3 FAs, studies of platelet function and platelet incorporation of these FAs will help define potential additional beneficial effects on cardiovascular risk. Studies of peripheral vascular reactivity will be perormed in these subjects at the initation and termination of the weight reduction period.