PHARMACOLOGICAL EFFECTS ON TIMING BEHAVIOR

本研究的目的是（a）应用一个定量的 时间的心理学理论与标准的心理物理学参考 （B）评价各种药物的作用 神经递质在定时性能，和（c）有关的 神经生物学变量到心理学变量。 实验 将在时间估计程序中用大鼠进行研究。 一 标量定时模型将被调整，以提供定量拟合 试验结果 该理论的参数可以确定为： 具体的心理变量，如“注意力”，“反应能力”， “时间敏感性”、“时钟速度”和“强化时间记忆”。" 甲基苯丙胺、氟哌啶醇和相关药物的研究将在 进行评估的假设，即内部时钟的速度 与多巴胺水平有关。 将进行其他研究， 确定什么神经递质机制可能负责 在施用加压素后改善的定时性能。 的 长期目标是确定神经递质在 更高的认知过程，如时间。 科学学科是 实验心理学和心理生物学。

The purpose of the proposed research is (a) to apply a quantitative psychological theory of timing to a standard psychophysical reference experiment for timing, (b) to evaluate the role of various neurotransmitters in timing performance, and (c) to relate the neurobiological variables to the psychological variables. Experimental studies will be conducted with rats in a temporal estimation procedure. A model of scalar timing will be adapted to provide a quantitative fit of experimental results. The parameters of the theory can be identified with specific psychological variables, such as "attention," "responsiveness," "sensitivity to time," "clock speed," and "memory of reinforced time." Studies with methamphetamine, haloperidol, and related drugs will be conducted to evaluate the hypothesis that the speed of the internal clock is related to the level of dopamine. Other studies will be conducted to determine what neurotransmitter mechanism might be responsible for the improved timing performance following administration of vasopressin. The long-range objective is to determine the role of neurotransmitters in higher cognitive processes, such as timing. The scientific disciplines are experimental psychology and psychobiology.