PHARMACOLOGICAL EFFECTS ON TIMING BEHAVIOR

拟议研究的目的是(A)应用定量的 以标准心理物理参照物为参照的计时心理学理论 实验计时，(B)评估各种因素的作用 神经递质在计时表现中的作用，以及(C)与 将神经生物学变量转化为心理变量。实验 研究将在时间估计程序中用老鼠进行。一个 标量计时模型将进行调整，以提供对 实验结果。这一理论的参数可以用以下公式来确定 特定的心理变量，如“注意力”、“反应能力”、 “对时间的敏感度”、“时钟速度”和“强化的时间记忆”。 甲基苯丙胺、氟哌啶醇和相关药物的研究将 对内部时钟的速度假设进行评估 与多巴胺水平有关。我们会进行其他研究，以 确定什么神经递质机制可能导致 改善了服用加压素后的计时表现。这个 长期目标是确定神经递质在 更高级的认知过程，如计时。科学学科包括 实验心理学和心理生物学。

The purpose of the proposed research is (a) to apply a quantitative psychological theory of timing to a standard psychophysical reference experiment for timing, (b) to evaluate the role of various neurotransmitters in timing performance, and (c) to relate the neurobiological variables to the psychological variables. Experimental studies will be conducted with rats in a temporal estimation procedure. A model of scalar timing will be adapted to provide a quantitative fit of experimental results. The parameters of the theory can be identified with specific psychological variables, such as "attention," "responsiveness," "sensitivity to time," "clock speed," and "memory of reinforced time." Studies with methamphetamine, haloperidol, and related drugs will be conducted to evaluate the hypothesis that the speed of the internal clock is related to the level of dopamine. Other studies will be conducted to determine what neurotransmitter mechanism might be responsible for the improved timing performance following administration of vasopressin. The long-range objective is to determine the role of neurotransmitters in higher cognitive processes, such as timing. The scientific disciplines are experimental psychology and psychobiology.