From Big to Small: domino-disassembled nanogels as new drug delivery vehicles

该项目旨在开发新型多米诺骨牌分解交联纳米凝胶，并评估其作为药物输送载体的潜在用途。分解聚合物的概念是新的，可以被描述为大分子系统能够分解成它们的组成部分，通过一个单一的刺激，如一个特定的化学反应，引发多米诺骨牌反应。在聚合物基质内建立交联网络将提供三维腔体，在那里与药物分子的特定相互作用可能更有利。选择纳米凝胶作为聚合物的形式，是由其在应用方面的巨大优势所决定的，因为这种材料能够形成胶体溶液。

This project aims to develop novel domino-disassembled cross-linked nanogels and to evaluate their potential use as drugdelivery vehicles. The concept of disassembling polymers is new and can be described as macromolecular systems able todisintegrate into their building blocks through a domino-like reaction triggered by a single stimulus, such as a specificchemical reaction. The creation of a cross-linking network within the polymeric matrix would provide three dimensionalcavities where specific interactions with the drug molecule could be favoured. The choice of nanogels, as polymer format,is dictated by the great advantages derived, in terms of applications, by having such materials able to form colloidalsolutions.