EPIDEMIOLOGY OF INSULIN AND DHEAS AND CHD MORTALITY

我们计划使用MRFIT参与者进行巢式病例对照研究， 为了确定：（1）血清胰岛素是否是冠心病的危险因素 DHEAS是否为CHD的危险因素 死亡率;（3）血清胰岛素水平的决定因素， 中年男子。 该研究将包括100例CHD死亡、100例MI和400例对照组， 年龄，以及是否在MRFIT试验中的常规或特殊护理参与者。 样品在-60--70 ℃下保存约15年。 死亡 自1974年以来在MRFIT研究中得到确认。 存活的MI受试者 在试验的积极阶段进行了仔细的评估， 1982. 根据最近的审查， 协调中心。 胰岛素和胰岛素之间的可能关系 或DHEAS和CHD死亡率将相对于其他主要CHD进行评价 危险因素包括总胆固醇、LDL、HDL、甘油三酯、空腹 1-小时血糖，收缩压和舒张压，BMI，身体 活动、教育、肺功能、吸烟和硫氰酸盐 程度.

We plan to do a nested case-control study using the MRFIT participants in order to determine whether; (1) serum insulin is a risk factor for CHD morbidity and mortality; (2) whether DHEAS is a risk factor for CHD mortality; and (3) the determinants of serum insulin levels among middle-aged men. The study will include 100 CHD deaths, 100 MI's, and 400 controls matched for age, and whether usual or special care participants in the MRFIT trial. Specimens have been stored at -60- -70C for about 15 years. Deaths have been ascertained in the MRFIT study since 1974. Surviving MI participants were carefully, evaluated during the active phase of the trial through 1982. Adequate numbers of cases are available based on recent reviews by the Coordinating Center. The possible relationship between either insulin or DHEAS and CHD mortality will be evaluated in relation to other major CHD risk factors including total cholesterol, LDL, HDL, triglycerides, fasting 1-hour blood sugar, systolic and diastolic blood pressure, BMI, physical activity, education, pulmonary function, cigarette smoking, and thiocynate levels.