DIETARY TREATMENT OF HYPERLIPIDEMIA IN WOMEN VS MEN

女性经历的动脉硬化疾病， 中风和心脏病，但因为女性经历过这些疾病， 在以后的生活中，心脏病，胆固醇和饮食的重要性 女性一直被低估。 这项研究是一项饮食研究， 干预试验，以测试对NCEP步骤的降脂反应 两种饮食方式对自由生活的高血脂症女性和男性进行比较， 他们之间的回应。 受试者将是波音公司的雇员 在西雅图地区，他们有两个独立的低密度测量 脂蛋白胆固醇（LDL-C），年龄-性别- 具体的第75百分位值，没有采取脂质改变 药物，并且已经没有比 研究饮食。 受试者被进一步归类为 高胆固醇血症（HC），仅LDL-C升高，或合并 在高脂血症（CHL）中，LDL-C和总甘油三酯均升高。 一半的受试者将随机接受2年的饮食指导 随访和半至6个月的无干预， 饮食指导和随访。对照组受试者将接受空腹血 在不干预期的3个月内提取。 具有平行 干预组和对照组是必要的，以测试的功效， NCEP第二步饮食：饮食将在8天内教授研究受试者 每周2小时课程。 随访将包括4次单独访视， 6个月、9个月和12个月，有一名营养师和2次小组会议，分别为4.5和 10.5在第一年进行了2个月的访问，在18岁和24岁进行了2次单独访问 几个月，在第二年。 用于脂蛋白脂质的空腹血液样本 将收集所有个体的分析和4天食物日记 探访 此外，病史，生活方式特征，重要 体征、其他依从性指标、与依从性相关的行为因素， 和监测营养充足的血清营养素， 收集。 营养师将提供坚持和饮食调整 必要时进行咨询，以帮助参与者最大限度地提高他们的依从性。 需要回答的主要问题是：1）NCEP第二步饮食是否 有效降低HC和CHL女性和6岁以上男性的血脂 几个月？2)HC和CHL女性的反应是否与HC和CHL不同 男人吗？3)女性的反应受月经状况和性别影响吗 荷尔蒙暴露？以及4）饮食的行为适应 女性和男性之间的变化不同吗？

Women experience as much illness from hardening of the arteries including stroke and heart disease as do men, but because women experience them later in life, the importance of heart disease, cholesterol, and diet for women has been under appreciated. The proposed study is a dietary intervention trial to test the lipid lowering response to the NCEP Step Two Diet by free-living hyperlipidemic women and men and to compare the response between them. Subjects will be employees of the Boeing Company in the Seattle area, who have two separate measurements of low density lipoprotein cholesterol (LDL-C) which are at or above the age- sex- specific 75th percentile value, are not taking lipid altering medications, and are not already on a diet more restrictive than the study diet. Subjects win be further classified as being hypercholesterolemic (HC), only LDL-C is elevated, or combined hyperlipidemic (CHL), both LDL-C and total triglyceride are elevated. Half of the subjects will be randomized to diet instruction with 2 years of follow-up and half to 6 months of no intervention followed by the same diet instruction and followup. Control subjects will have a fasting blood draw at 3 months of the nonintervention period. Having parallel intervention and control groups is necessary to test the efficacy of the NCEP Step Two Diet: The diet will be taught to study subjects during 8 weekly 2 hour classes. Follow-up will include 4 individual visits, at 3, 6, 9, and 12 months, with a dietitian and 2 group sessions, at 4.5 and 10.5 months, in the first year and 2 individual visits, at 18 and 24 months, in the second year. Fasting blood samples for lipoprotein lipid analysis and 4-day food diaries will be collected at all individual visits. Additionally, medical history, lifestyle characteristics, vital signs, other adherence measures, behavioral factors related to adherence, and serum nutrients for monitoring nutrient sufficiency will be collected. Dietitians will provide adherence and dietary modification counseling as necessary to help participants maximize their adherence. The primary questions to be answered are: 1) Does the NCEP Step Two Diet effectively lower plasma lipids in HC and CHL women and men over 6 months? 2) Do HC and CHL women have a different response than HC and CHL men? 3) Is response in women influenced by menstrual status and sex hormone exposure?, and 4) Are the behavioral adaptations to dietary modification different between women and men?