Asymmetric Cross-Coupling via Iron-Catalysed Reductive Cross-Coupling

复杂分子框架的构建为从新药到新材料的一切未来发展奠定了基础。制造碳-碳键的能力是这一发展的关键。进行这种成键反应的一些最常用的方法依赖于使用昂贵的、有毒的和对环境有害的过渡金属催化剂。这一研究方案旨在开发铁基替代目前使用的方法，并扩大目前转型的范围和适用性。铁催化剂具有价格低廉、无毒、对环境友好等优点，因此受到化学界的极大关注。具体地说，我们将引入一种新的碳-碳键形成反应，同时还原生成完全饱和的产物(烷烃)。

The construction of complex molecular frameworks underpins the future development of everything from new medicines to novel materials. The ability to make carbon-carbon bonds is key to this development. A number of the most used methods to carry out this bond forming reaction rely on the use of expensive, toxic and environmentally damaging transition-metal catalysts. This research programme aims to develop iron-based alternatives to the currently used methods and expand upon the scope and applicability of the current transformations. Iron catalysts offer the advantage of being inexpensive, non-toxic and environmentally benign and so are of great interest to the chemical community. Specifically, we will introduce a new carbon-carbon bond forming reaction with a concurrent reduction to produce fully saturated products (alkanes).