CLINICAL AUDIOVESTIBULAR ASSESSMENT OF PANIC ATTACKS

这项研究涉及有或没有广场恐惧症的惊恐障碍， 与紧张的精神状态相关的精神状态 不适和严重的社交能力丧失，并影响 1000万美国人。这项研究是基于一项试点的结果 调查表明，这与 惊恐障碍和前庭和前庭的异常表现 听力学测试。 我们建议对耳神经科进行对照评估。 病例对照设计中惊恐障碍的功能。我们会 对比听力前庭异常发现的发生率 五个不同的诊断小组：(1)没有惊恐障碍 广场恐惧症；(2)伴广场恐惧症的惊恐障碍；(3)泛化 焦虑症；(4)恶劣心境障碍；(5)正常(没有 精神障碍)。在初步诊断评估后，46 每组的受试者，即总共230名受试者，将获得 一组临床听力学和前庭测试。这个 前庭测试包括：运动平台姿势图， 旋转、位置和卡路里测试。听力学测试 包括：鼓室导纳、纯音和语音辨别 听力图、单侧和交叉性声反射和听觉 脑干诱发电位。听力学的评价者 而前庭测试将无法诊断出 研究对象。 这些测试的结果将根据以下方面进行检查 临床异常发现的患病率。此外， 对未经处理的数据进行参数分析将测试系统 诊断组之间在整个正常和 异常范围。恐慌现象学与心理恐慌的关系 前庭异常也会被检查。的影响 过度换气对前庭功能的影响将被研究。这个 这项研究的结果将对临床应用产生影响。 惊恐障碍的治疗和评估。

This study concerns panic disorder with or without agoraphobia, psychiatric conditions which are associated with intense discomfort and significant social incapacitation, and which affect 10 million Americans. The study is based on the results of a pilot investigation, which suggested that there was an association between panic disorder and abnormal findings on vestibular and audiological tests. We are proposing a controlled evaluation of otoneurological function in panic disorder in a case-control design. We will contrast the prevalence of abnormal audiovestibular findings across five different diagnostic groups: (1) Panic disorder without agoraphobia; (2) Panic disorder with agoraphobia; (3) Generalized Anxiety disorder; (4) Dysthymic disorder; and (5) Normals (no psychiatric disorder). After initial diagnostic evaluations, 46 subjects of each group, or a total of 230 subjects, will receive a battery of clinical audiological and vestibular tests. The vestibular tests include: moving platform posturography, rotational, positional and caloric tests. The audiological test include: tympanometry, pure tone and speech discrimination audiograms, unilateral and crossed acoustic reflexes and auditory brain stem evoked potentials. The evaluators of the audiological and vestibular tests will be blind as to the diagnosis of the subjects. The results of these tests will be examined with respect to prevalence of clinically abnormal findings. Furthermore, parametric analysis of unprocessed data will test for systematic differences between diagnostic groups over the entire normal and abnormal range. The relationship between panic phenomenology and vestibular anomalies will be examined. The effect of hyperventilation on vestibular function will be studied. The results of the study will have clinical implications for the treatment and assessment of panic disorder.