ENDOGENOUS ERPS IN OBSESSIVE-COMPULSIVE DISORDER

先前的研究已经发现了与脑事件相关的 强迫症（OCD）中的ERP，例如，减少 N200/P300潜伏期和增强的负性。 我们的长期目标是 有助于澄清中枢神经系统机制的性质， 通过评估强迫症患者和对照组之间的差异， 内源性ERP组件，其中每一个被认为是反映了一个 信息处理的特定阶段。 被动和主动注意 任务将用于识别N200中的特定组件， P300复合物在强迫症患者中改变。 任务旨在 测量注意力相关的处理负性（Nd）和偶然性 负变异（CNV）将检验关于存在的假设 过度集中注意力过度怀疑和不确定性 此外，ERP组件的横向不对称性和 二分音节任务的认知不对称性将提供数据， 评估左半球过度激活和功能障碍的假设 强迫症 拟议的项目还将调查：a）诊断 使用社交恐惧控制的强迫症ERP结果的特异性 B）ERP异常与症状类型之间的关系， 强迫症的严重程度;以及c）强迫症中的关键ERP异常是否代表 治疗成功后的稳定（性状）特征或变化 服用抗强迫症药物 具体而言，40名强迫症患者，20名社交恐惧症对照组和20名正常人 控制将测试四个ERP任务;被动注意力任务， 主动注意任务、定向注意任务和选择反应 时间CNV任务，以及两分辅音-元音辨别 任务 强迫症患者和社交恐惧症患者在服用最少的药物后接受测试- 14天的自由期，强迫症患者在12周后重新测试 在大多数情况下， 例 正常对照将在相同的重测时进行重测 像强迫症患者一样。

Prior studies have found distinctive alterations of brain event-related potentials (ERPs) in obsessive-compulsive disorder (OCD), e.g., reduced N200/P300 latency and enhanced negativities. Our long range goal is to help clarify the nature of the CNS mechanisms that may be different in OCD by assessing differences between OCD patients and controls in endogenous ERP components, each of which is thought to reflect a specific stage of information processing. Passive and active attention tasks will be used to identify the specific components within the N200- P300 complex that are altered in OCD patients. Tasks designed to measure attention-related processing negativity (Nd) and the contingent negative variation (CNV) will test hypotheses concerning the existence of overfocused attention and excessive doubt and uncertainty in OCD. Also, relationships between lateral asymmetries of ERP components and cognitive asymmetries for a dichotic syllable task will provide data for evaluating hypotheses of left hemisphere overactivation and dysfunction in OCD. The proposed project will also investigate: a) the diagnostic specificity of ERP findings for OCD by using a social phobic control group; b) relationships between ERP abnormalities and symptom type and severity in OCD; and c) whether key ERP abnormalities in OCD represent stable (trait) characteristics or change following successful treatment with an antiobsessional medication. Specifically, 40 OCD patients, 20 social phobic controls and 20 normal controls will be tested on four ERP tasks; a Passive Attention Task, an Active Attention Task, a Directed Attention Task and a Choice Reaction Time CNV Task, as well as on a dichotic consonant-vowel discrimination task. OCD patients and social phobics are tested after a minimum drug- free period of 14 days, and OCD patients are retested following 12 weeks of treatment with an antiobsessional mediation, fluoxetine in most cases. Normal controls will be retested at the same test-retest intervals as OCD patients.