GENE MARKERS IN SCHIZOPHRENIA AND OTHER PSYCHOSES

这项建议的主要目标是检测人类基因组中的主要基因。 精神分裂症和其他精神病的分子传播 基因技术，并阐明遗传关系 在精神分裂症和情感障碍的亚群之间 其他可能相关的精神病患者。这一目标将通过以下方式实现 1.收集分离的大型高密度家系 精神分裂症谱系或与双相情感相关的主要情感 2.进行与DNA标记的连锁研究 合适的血统。如果建立了联系(或联系)， 研究还将致力于确定有关联和无关联的病例的特征 临床措施，试图识别和定义 这些疾病的同类子集。长期目标将 包括缺陷的识别和表征 基因(S)和相关生物制品，以及评估 基因与环境的相互作用。要研究的人群是 纽约布鲁克林的卢巴维奇·哈西德社区 具有强大创始人的具有遗传和文化凝聚力的集团 影响和确立的欧洲血统可以追溯到18世纪 世纪。已知的具有大兄弟姐妹关系的多代家系 家谱根源、近亲交配效应和较低的 酗酒、吸毒、犯罪和暴力行为、条件 这混淆了精神疾病的诊断，使这一点 人群对精神疾病的遗传学研究尤为重要 精神错乱。 独特人口的可用性，加上最近 方法学上的进步，如分子遗传技术， 系统地获取家庭数据的方法，结构化 访谈，精准的诊断标准和更高的可靠性， 以及一系列的遗传模型，为解开 构成主要精神病的遗传机制。这, 反过来，可能会对病因学、病因学、 病理生理学以及可能的预防和治疗 精神错乱。

The main objective of this proposal is to detect major genes in the transmission of schizophrenia and other psychoses using molecular genetic techniques, and to elucidate the genetic relationship between subsets of schizophrenic and affective disorders and other potentially related psychoses. This goal will be attained by 1. collecting large high density pedigrees segregating schizophrenia spectrum or bipolar-related major affective disorders; and 2. conducting linkage studies with DNA markers in suitable pedigrees. Should linkage (or linkages) be established, the study will also aim to characterize linked versus unlinked cases on clinical measures in an attempt to identify and define homogeneous subsets of these disorders. Long-term goals will include the identification and characterization of the defective gene(s) and the associated biological products, and the assessment of gene-environment interaction. The population to be studied is the Lubavitch Hassidic community in Brooklyn, New York, a genetically and culturally cohesive group with strong founder effects and established European ancestry dating back to the 18th century. Multigenerational pedigrees with large sibships, known genealogical roots, inbreeding effects, and low rates of alcoholism, drug abuse, crimes and acts of violence, conditions that confound the diagnosis of mental illness, render this population especially important for genetic studies of mental disorders. The availability of a unique population, coupled with recent methodological advances such as molecular genetic techniques, approaches to systematically obtaining family data, structured interviews, precise diagnostic criteria with improved reliability, and a range of genetic models, holds much promise for unraveling the genetic mechanisms that underlie the major psychoses. This, in turn, could have major implications for the etiology, nosology, pathophysiology and, possibly, prevention and treatment of these disorders.