GENE MARKERS IN SCHIZOPHRENIA AND OTHER PSYCHOSES

这项建议的主要目的是检测主要基因在 精神分裂症和其他精神病的分子传播 基因技术，并阐明遗传关系 精神分裂症和情感性精神障碍之间的联系， 其他可能相关的精神病。 这一目标将通过以下方式实现： 1.收集大的高密度谱系， 精神分裂症谱系或双极相关主要情感 疾病;和2.利用DNA标记进行连锁研究， 合适的血统。 如果建立联系， 这项研究还将旨在描述与关联和非关联病例的特征， 临床措施，试图识别和定义 这些疾病的同质子集。 长期目标将 包括缺陷的识别和表征 基因和相关生物制品，以及评估 基因与环境的相互作用。 拟研究的人群为 纽约布鲁克林的卢巴维奇哈西德社区， 具有强大创始人的基因和文化凝聚力的群体 影响和建立欧洲血统可以追溯到18世纪 世纪。 多代血统与大的兄弟姐妹，已知 系谱根源，近亲繁殖的影响，和低利率的 酗酒、吸毒、犯罪和暴力行为， 混淆了对精神疾病的诊断， 对精神疾病的遗传学研究特别重要的人群 紊乱 一个独特的人口的可用性，加上最近的 方法学的进步，如分子遗传技术， 有系统地获取家庭数据的方法， 访谈，具有更高可靠性的精确诊断标准， 以及一系列的遗传模型， 主要精神病的遗传机制 这个， 反过来，可能对病因学，疾病分类学， 病理生理学，以及可能的预防和治疗这些 紊乱

The main objective of this proposal is to detect major genes in the transmission of schizophrenia and other psychoses using molecular genetic techniques, and to elucidate the genetic relationship between subsets of schizophrenic and affective disorders and other potentially related psychoses. This goal will be attained by 1. collecting large high density pedigrees segregating schizophrenia spectrum or bipolar-related major affective disorders; and 2. conducting linkage studies with DNA markers in suitable pedigrees. Should linkage (or linkages) be established, the study will also aim to characterize linked versus unlinked cases on clinical measures in an attempt to identify and define homogeneous subsets of these disorders. Long-term goals will include the identification and characterization of the defective gene(s) and the associated biological products, and the assessment of gene-environment interaction. The population to be studied is the Lubavitch Hassidic community in Brooklyn, New York, a genetically and culturally cohesive group with strong founder effects and established European ancestry dating back to the 18th century. Multigenerational pedigrees with large sibships, known genealogical roots, inbreeding effects, and low rates of alcoholism, drug abuse, crimes and acts of violence, conditions that confound the diagnosis of mental illness, render this population especially important for genetic studies of mental disorders. The availability of a unique population, coupled with recent methodological advances such as molecular genetic techniques, approaches to systematically obtaining family data, structured interviews, precise diagnostic criteria with improved reliability, and a range of genetic models, holds much promise for unraveling the genetic mechanisms that underlie the major psychoses. This, in turn, could have major implications for the etiology, nosology, pathophysiology and, possibly, prevention and treatment of these disorders.