CLINICAL AUDIOVESTIBULAR ASSESSMENT OF PANIC ATTACKS

这项研究涉及惊恐障碍伴或不伴广场恐怖症， 精神状况，与强烈的 不适和严重的社会失能， 一千万美国人。 这项研究是基于一个试点的结果， 调查表明，有一个协会， 惊恐障碍和前庭神经异常之间的关系， 听力测试 我们建议对耳神经系统疾病 在惊恐障碍中的作用。 我们将 对比异常听前庭检查结果的患病率 在五个不同的诊断组：（1）恐慌症， 广场恐怖症;（2）惊恐障碍伴广场恐怖症;（3）全身性 焦虑障碍;（4）心境恶劣障碍;和（5）正常人（无 精神障碍）。 经过初步诊断评估，46 每组的受试者，或总共230名受试者，将接受 一系列临床听力学和前庭测试。 的 前庭测试包括：移动平台姿势描记法， 旋转位置和热量测试 听力测试 包括：鼓室导抗测试、纯音和言语辨别 听力图，单侧和交叉声反射和听觉 脑干诱发电位 听力学评估者 前庭测试将盲目的诊断 科目 这些测试的结果将在以下方面进行检查： 临床异常结果的患病率。 此外，委员会认为， 未处理数据的参数分析将测试系统 诊断组之间在整个正常范围内的差异 异常范围 恐慌现象学与 和前庭异常的检查 的影响 将研究过度换气对前庭功能的影响。 的 这项研究的结果将有临床意义， 惊恐障碍的治疗和评估。

This study concerns panic disorder with or without agoraphobia, psychiatric conditions which are associated with intense discomfort and significant social incapacitation, and which affect 10 million Americans. The study is based on the results of a pilot investigation, which suggested that there was an association between panic disorder and abnormal findings on vestibular and audiological tests. We are proposing a controlled evaluation of otoneurological function in panic disorder in a case-control design. We will contrast the prevalence of abnormal audiovestibular findings across five different diagnostic groups: (1) Panic disorder without agoraphobia; (2) Panic disorder with agoraphobia; (3) Generalized Anxiety disorder; (4) Dysthymic disorder; and (5) Normals (no psychiatric disorder). After initial diagnostic evaluations, 46 subjects of each group, or a total of 230 subjects, will receive a battery of clinical audiological and vestibular tests. The vestibular tests include: moving platform posturography, rotational, positional and caloric tests. The audiological test include: tympanometry, pure tone and speech discrimination audiograms, unilateral and crossed acoustic reflexes and auditory brain stem evoked potentials. The evaluators of the audiological and vestibular tests will be blind as to the diagnosis of the subjects. The results of these tests will be examined with respect to prevalence of clinically abnormal findings. Furthermore, parametric analysis of unprocessed data will test for systematic differences between diagnostic groups over the entire normal and abnormal range. The relationship between panic phenomenology and vestibular anomalies will be examined. The effect of hyperventilation on vestibular function will be studied. The results of the study will have clinical implications for the treatment and assessment of panic disorder.