FUNCTIONAL ASYMMETRY--COGNITIVE DEFICIENCIES

先前的研究表明，精神分裂症患者 在某些方面表现出明显更大的不对称性 形态特征(例如，皮纹)比正常或 情绪紊乱的受试者。人们一直认为这是一种 不对称反映了与以下因素相关的“波动不对称” 在许多不同的基因座上存在高水平的纯合性。 对其他多基因疾病的研究表明，波动 不对称性可作为多基因遗传的标记。 因此，观察到，作为一个群体，精神分裂症 受试者表现出明显的波动不对称性表明一种新的 检验关于这一基因底物的假设的方法 无序。 这份提案概述了旨在检查1) 理论上认为，认知任务的表现与 是否为精神分裂症易感标志物和波动程度 皮纹性状的不对称性；2)两者之间的关系 皮纹不对称和偏离正常模式 大脑偏侧化的关系3)大脑偏侧化 皮纹不对称和某些分组策略 精神分裂症。

Previous research has demonstrated that schizophrenic subjects exhibit a significantly greater degree of asymmetry on certain morphological traits (e.g., dermatoglyphics) than normal or affectively disordered subjects. It has been assumed that this asymmetry reflects the "fluctuating asymmetry" associated with high levels of homozygosity at a number of different loci. Research on other polygenic disorders has shown that fluctuating asymmetry can be used as a marker of polygeneic inheritance. Therefore, the observation that, as a group, schizophrenic subjects show marked fluctuating asymmetry suggests a new method for testing hypotheses about the genetic substrate of this disorder. This proposal outlines experiments designed to examine 1) the association between performance on cognitive tasks theorized to be schizophrenic vulnerability markers and degree of fluctuating asymmetry in dermatoglyphic traits; 2) the relationship between dermatoglyphic asymmetry and deviations from normal patterns of cerebral lateralization 3) the relationship between dermatoglyphic asymmetry and certain subgrouping strategies for schizophrenia.