CEREBRAL CORTICAL CONTROL OF MOVEMENT

拟议研究的目的是加深我们对 运动皮质控制运动，并随后有助于更好地 人类运动功能障碍的治疗。在过去的几年里，我们已经 显示运动皮质直接接受来自 而不是通过感觉皮质。我们已经证明了有 运动皮质内控制收缩的皮质传出区 单独的肌肉，因此运动皮质和外周通过 最简单的环路。 在接下来的几年里，我们计划阐明它的功能意义 各种输入汇聚到运动皮质。这将通过以下方式完成 将微刺激传递到中枢神经系统的不同部分 使用皮质-外周环路检查效果。这项研究将 希望探索对运动皮质的进一步见解，并产生知识， 将适用于患者的治疗。

The purpose of the proposed study is to increase our understanding of how the motor cortex controls movement and subsequently to contribute toward the better treatment of human motor dysfunctions. During the past grant years, we have shown that the motor cortex receives peripheral inputs directly from the thalamus and not through the sensory cortex. We have already shown there are cortical efferent zones within the motor cortex which control contraction of individual muscles, hence the motor cortex and the periphery are connected by the simplest loop circuit. During the coming years, we plan to elucidate the functional significance of various inputs converging into the motor cortex. This will be done by delivering microstimulation to various parts of the central nervous system and examining the effects using the cortico-peripheral loop circuit. The study will hopefully explore further insights of the motor cortex and yield knowledge which will be applicable to the treatment of the patients.