STIMULUS CODING BY SOMATOSENSORY CORTEX

描述（改编自申请人摘要）：本提案包含 两个部分，一个实验和一个理论，在一个综合的攻击， 躯体感觉皮层的功能 动物实验将 利用几种方法，包括细胞外多单位记录 用于监测单个神经元或小皮层的响应的方法 精确控制振动触觉和移动触觉 刺激; 14-C-2-DG代谢作图技术用于证明 躯体感觉皮层的空间模式化整体反应 重复的自然刺激。 药物对多种细胞具有选择性作用 将施用新皮层系统。 所获得的信息 该项目的各个阶段将作为研究的实验基础， 躯体感觉皮层信息表征和处理的模型。 这些发现预计将直接影响最近提出的观点， 皮层动态外-柱和内-柱侧抑制相互作用 这表明皮层神经传递的作用非常特殊。 这 结合动物和计算机建模研究，旨在提供 深入了解大脑皮层的动态机制， 自然发生的感知相关刺激的表示。

DESCRIPTION (Adapted from Applicant's Abstract): This proposal contains two parts, one experimental and one theoretical, in an integrated attack on the function of somatosensory cortex. The animal experimentation will utilize several methods, including extracellular multiunit recording methods for monitoring response of single neurons or small cortical populations to precisely controlled vibrotactile and moving tactile stimuli; the 14-C-2-DG metabolic mapping technique for demonstrating the spatially patterned global response of the somatosensory cortex to repetitive natural stimuli. Drugs having selective actions on various neocortical systems will be administered. The information obtained at all stages of the project will serve as the experimental basis for studies of a model of somatosensory cortical information representation and processing. These findings are expected to bear directly on a recently proposed view of cortical dynamic peri- and intra-columnar lateral inhibitory interactions which suggest highly specific roles for cortical neurotransmission. This combination of animal and computer modelling studies is intended to provide in-depth information about the dynamical cortical mechanisms involved in the representation of naturally occurring perceptually relevant stimuli.