NURSING ASSESSMENT OF PMS--NEUROMETRIC INDICES

本研究的目的是：(A)描述、比较和对比 通过使用神经测量学分析脑功能的模式 有围绝经期骚动症状的妇女和没有或轻微的妇女 孕周症状，以及；(B)确定性交模式之间的联系 大脑功能伴随着性周症状、焦虑、抑郁和 产后和围绝经期的皮质醇水平 有症状和无症状的妇女。以下是研究问题 将被调查：1.有围生期骚乱的女性有没有 精神病理的发生率比无症状的妇女更高？2.有没有 大脑功能与经期症状之间的关系， 焦虑、抑郁、皮质醇水平与应激性生活事件 围绝经期妇女的月经后和经周阶段 骚乱和无症状的女性？3.是否有不同的模式 女性月经后和围绝经期的脑功能 月经周期有周围性骚动的女性和 有无症状吗？4.有不同的大脑功能模式吗 女性跨月经周期阶段(经后和经周) 有围绝经期骚乱和没有症状的女性吗？5.大脑 有类似或不同围绝经期骚动的女性的功能 根据神经测量建立的模式组织起来，适用于患有 精神病学严重情感障碍？6.围生期亚型 根据大脑功能的模式，通过 使用神经测量分析吗？这项研究使用了一种自然主义的描述性 用于评估有症状和无症状的妇女的纵向设计 用于围绝经期的动乱症状。女性将接受筛查 符合资格并通过以下途径进入有症状和无症状组 电话采访。约500名符合条件的参与者将 完成三个完整月经周期的每日健康日记 小组安置的确认。250名参与者的最终样本 (125名有症状和125名无症状)将在 完整的月经周期。测量抑郁、焦虑、皮质醇和 黄体酮水平和生活压力事件会发生1到2次 每周一次，以及每天的症状感知..这些措施将 也可在月经后7-10天和-3-+2之间获得 围产期天数及qEEG测量。一种组合 卡方、逐步多元回归及协方差分析 用来解决研究问题。

The purposes of this research are to: (a) describe, compare, and contrast patterns of brain function through the use of neurometric analyses in women with perimenstrual turmoil symptoms and in women with no or mild perimenstrual symptoms, and; (b) determine the association of patterns of brain function with perimenstrual symptoms, anxiety, depression, and cortisol levels during postmentrual and perimenstrual phases among the symptomatic and asymptomatic women. The following research questions will be investigated: 1. Do women with perimenstrual turmoil have a higher incidence of psychopathology than asymptomatic women? 2. Is there a relationship between brain function and perimenstrual symptoms, anxiety, depression, cortisol levels and stressful life events during postmenstrual and perimenstrual phases in women with perimenstrual turmoil and in asymptomatic women? 3. Are there different patterns of brain function during postmenstrual and perimenstrual phases of the menstrual cycle between women with perimenstrual turmoil and women who are asymptomatic? 4. Are there different patterns of brain function across menstrual cycle phases (postmenstrual and perimenstrual) in women with perimenstrual turmoil and women who are asymptomatic? 5. Is brain function in women with perimenstrual turmoil similar to or differently organized from neurometrically established patterns for women with Psychiatric Major Affective Disorder? 6. Can subtypes of perimenstrual turmoil be differentiated based on patterns of brain function through the use of neurometric analysis? The study uses a naturalistic descriptive longitudinal design to assess women who are symptomatic and asymptomatic for perimenstrual turmoil symptoms. Women will be screened for eligibility and placement into symptomatic and asymptomatic groups via a telephone inter-view. Approximately 500 eligible participants will complete a daily health diary for three complete menstrual cycles for confirmation of group placement. A final sample for 250 participants (125 symptomatic and 125 asymptomatic) will be followed closely during a complete menstrual cycle. Measures of depression, anxiety, cortisol and progesterone levels, and life stress events will be taken 1 to 2 times weekly along with daily perceptions of symptoms.. These measures will also be obtained between 7-10 days postmenstrually and between -3 to +2 days perimenstrually along with QEEG measurement. A combination of Chi-square, stepwide multiple regression and analysis of covariance will be used to address the research questions.