MESOCORTICAL ANATOMY AND PLASTICITY

一个持续的计划概述，具有双重目的， 研究大脑边缘系统产生的皮层神经系统 非人灵长类动物肝叶的病理改变 它们可能的同源物在阿尔茨海默氏症中出现。 的 边缘或中皮层形成内侧表面的主要部分 包括扣带回等区域 皮质、海马旁皮质、后眶额皮质和 颞极的皮层 校长的中心目标 研究人员的研究工作一直是阐明 中皮质与等皮质联合的关系 区域和形成海马结构的异皮质。 一个有利可图的除了目标，这已经演变了过去 5年来，一直致力于研究阿尔茨海默病的病理模式 从实验结果来看， 神经解剖学研究。 非人类灵长类动物实验研究， 这仍然是赠款的核心，建立连接， 中皮层神经元，病理学研究有助于建立 他们可能破坏了自然发生的人类疾病 针对中皮层 中皮层的五个区域 接受进一步调查。 包括颞极区， 内嗅的、嗅周的、枕颞的和后扣带回的 皮质 在猴子身上进行实验研究的目的将集中在 投射到皮层的中皮层轴突的起源 关于其地形、层流的联合区 投射神经元的组织和分离， 离散和非离散人口。 有关下列方面的调查： 阿尔茨海默氏病将检查细胞结构同源物 在人类大脑的这些区域，重点是地形 和层状组织的病理学使用两个标准 病理染色和单克隆抗体Alz-50。 动机 根据以往的研究进展，推测中皮层神经元 将大脑皮层的关联区域与 海马结构是阿尔茨海默病病理学靶点 疾病 神经系统疾病中这种关系的破坏 会导致记忆力情感和注意力的衰弱 个别调查具有成本效益， 收集了大量的实验材料， 在过去的19年里，他是哈佛医学中心的首席研究员， 学校（1969-1978年）和爱荷华州大学（1979年至今）。 此外，超过70例患者的完全颞叶阻滞， 阿尔茨海默病在主要研究者的 实验室在过去的7年里。

A continuing plan is outlined that has the dual purpose of investigating cortical neural systems that arise from the limbic lobe in the nonhuman primate and the pathological alteration of their probable homologues as seen in Alzheimer's disease. The limbic, or mesocortices, form a major part of the medial surface of the primate brain and include such areas as the cingulate cortex, parahippocampal cortex, posterior orbitofrontal cortex and the cortex of the temporal pole. The central goal of the principal investigator's research effort has been to elucidate the relationship of the mesocortices with the isocortical association areas and the allocortices that form the hippocampal formation. A profitable addition to the aims, that has evolved over the past 5 years, has been to cast the patterns of pathology in Alzheimer's disease in the perspective of results from experimental neuroanatomical studies. Nonhuman primate experimental studies, which remain the core of the grant, establish the connectivity of mesocortical neurons, and pathological studies serve to establish their probable disruption in a naturally occurring human illness that targets the mesocortex. Five areas of the mesocortex will receive further investigation. These include the temporal polar, entorhinal, perirhinal, occipitotemporal and posterior cingulate cortices. The aims of experimental studies in monkeys will focus on the origin of mesocortical axons that project to cortical association areas with regard to their topography, laminar organization and the segregation of projection neurons into discrete and nondiscrete populations. Investigations relating to Alzheimer's disease will examine the cytoarchitectural homologues of these areas in the human brain, with a focus on the topography and laminar organization of pathology using both standard pathological stains and the monoclonal antibody Alz-50. Motivated by previous progress, it is hypothesized that mesocortical neurons that interconnect the cortical association areas with the hippocampal formation are targeted for pathology in Alzheimer's disease. Disruption of this relationship in neurological disease yields debilitating disorders of memory, emotion and attention. The individual investigations are cost effective and draw in part on a large collection of experimental material gathered by the principal investigator over the past 19 years ar Harvard Medical School (1969-1978) and the University of Iowa (1979-present). Additionally, complete temporal lobe blocks from over 70 cases of Alzheimer's disease processed in the principal investigator's laboratory over the past 7 years are available.